A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines

The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which...

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Detalles Bibliográficos
Autores principales: Li, Li, Zhang, Qianqian, Liu, Bo, Liu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269788/
https://www.ncbi.nlm.nih.gov/pubmed/23681055
http://dx.doi.org/10.3390/molecules18055697
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author Li, Li
Zhang, Qianqian
Liu, Bo
Liu, Gang
author_facet Li, Li
Zhang, Qianqian
Liu, Bo
Liu, Gang
author_sort Li, Li
collection PubMed
description The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff’s base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation.
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spelling pubmed-62697882018-12-14 A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines Li, Li Zhang, Qianqian Liu, Bo Liu, Gang Molecules Article The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff’s base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation. MDPI 2013-05-16 /pmc/articles/PMC6269788/ /pubmed/23681055 http://dx.doi.org/10.3390/molecules18055697 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Li
Zhang, Qianqian
Liu, Bo
Liu, Gang
A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_full A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_fullStr A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_full_unstemmed A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_short A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
title_sort novel multi-component reaction to imidazo[4,5-g]-quinazolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269788/
https://www.ncbi.nlm.nih.gov/pubmed/23681055
http://dx.doi.org/10.3390/molecules18055697
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