Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives

New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discr...

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Detalles Bibliográficos
Autores principales: Mickevičius, Vytautas, Voskienė, Aušra, Jonuškienė, Ilona, Kolosej, Ramūnė, Šiugždaitė, Jūratė, Venskutonis, Petras Rimantas, Kazernavičiūtė, Rita, Brazienė, Zita, Jakienė, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269796/
https://www.ncbi.nlm.nih.gov/pubmed/24317527
http://dx.doi.org/10.3390/molecules181215000
Descripción
Sumario:New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.

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