Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives

New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discr...

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Detalles Bibliográficos
Autores principales: Mickevičius, Vytautas, Voskienė, Aušra, Jonuškienė, Ilona, Kolosej, Ramūnė, Šiugždaitė, Jūratė, Venskutonis, Petras Rimantas, Kazernavičiūtė, Rita, Brazienė, Zita, Jakienė, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269796/
https://www.ncbi.nlm.nih.gov/pubmed/24317527
http://dx.doi.org/10.3390/molecules181215000
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author Mickevičius, Vytautas
Voskienė, Aušra
Jonuškienė, Ilona
Kolosej, Ramūnė
Šiugždaitė, Jūratė
Venskutonis, Petras Rimantas
Kazernavičiūtė, Rita
Brazienė, Zita
Jakienė, Elena
author_facet Mickevičius, Vytautas
Voskienė, Aušra
Jonuškienė, Ilona
Kolosej, Ramūnė
Šiugždaitė, Jūratė
Venskutonis, Petras Rimantas
Kazernavičiūtė, Rita
Brazienė, Zita
Jakienė, Elena
author_sort Mickevičius, Vytautas
collection PubMed
description New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.
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spelling pubmed-62697962018-12-20 Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives Mickevičius, Vytautas Voskienė, Aušra Jonuškienė, Ilona Kolosej, Ramūnė Šiugždaitė, Jūratė Venskutonis, Petras Rimantas Kazernavičiūtė, Rita Brazienė, Zita Jakienė, Elena Molecules Article New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content. MDPI 2013-12-05 /pmc/articles/PMC6269796/ /pubmed/24317527 http://dx.doi.org/10.3390/molecules181215000 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mickevičius, Vytautas
Voskienė, Aušra
Jonuškienė, Ilona
Kolosej, Ramūnė
Šiugždaitė, Jūratė
Venskutonis, Petras Rimantas
Kazernavičiūtė, Rita
Brazienė, Zita
Jakienė, Elena
Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
title Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
title_full Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
title_fullStr Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
title_full_unstemmed Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
title_short Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
title_sort synthesis and biological activity of 3-[phenyl(1,3-thiazol-2-yl)-amino]propanoic acids and their derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269796/
https://www.ncbi.nlm.nih.gov/pubmed/24317527
http://dx.doi.org/10.3390/molecules181215000
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