Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh

Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds...

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Autores principales: Kim, Rosalind Pei Theng, Bihud, Vicky, bin Mohamad, Khalit, Leong, Kok Hoong, bin Mohamad, Jamaludin, bin Ahmad, Fasihuddin, Hazni, Hazrina, Kasim, Noraini, Halim, Siti Nadiah Abdul, Awang, Khalijah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269811/
https://www.ncbi.nlm.nih.gov/pubmed/23344192
http://dx.doi.org/10.3390/molecules18010128
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author Kim, Rosalind Pei Theng
Bihud, Vicky
bin Mohamad, Khalit
Leong, Kok Hoong
bin Mohamad, Jamaludin
bin Ahmad, Fasihuddin
Hazni, Hazrina
Kasim, Noraini
Halim, Siti Nadiah Abdul
Awang, Khalijah
author_facet Kim, Rosalind Pei Theng
Bihud, Vicky
bin Mohamad, Khalit
Leong, Kok Hoong
bin Mohamad, Jamaludin
bin Ahmad, Fasihuddin
Hazni, Hazrina
Kasim, Noraini
Halim, Siti Nadiah Abdul
Awang, Khalijah
author_sort Kim, Rosalind Pei Theng
collection PubMed
description Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC(50) value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC(50) of 0.207 µM.
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spelling pubmed-62698112018-12-14 Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh Kim, Rosalind Pei Theng Bihud, Vicky bin Mohamad, Khalit Leong, Kok Hoong bin Mohamad, Jamaludin bin Ahmad, Fasihuddin Hazni, Hazrina Kasim, Noraini Halim, Siti Nadiah Abdul Awang, Khalijah Molecules Article Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC(50) value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC(50) of 0.207 µM. MDPI 2012-12-21 /pmc/articles/PMC6269811/ /pubmed/23344192 http://dx.doi.org/10.3390/molecules18010128 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kim, Rosalind Pei Theng
Bihud, Vicky
bin Mohamad, Khalit
Leong, Kok Hoong
bin Mohamad, Jamaludin
bin Ahmad, Fasihuddin
Hazni, Hazrina
Kasim, Noraini
Halim, Siti Nadiah Abdul
Awang, Khalijah
Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_full Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_fullStr Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_full_unstemmed Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_short Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_sort cytotoxic and antioxidant compounds from the stem bark of goniothalamus tapisoides mat salleh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269811/
https://www.ncbi.nlm.nih.gov/pubmed/23344192
http://dx.doi.org/10.3390/molecules18010128
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