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A Facile Fabrication of Alginate Microbubbles Using a Gas Foaming Reaction

Microbubble particles have been extensively utilized as temporal templates for various biomedical applications. This study proposes a facile strategy to obtain microbubble-containing alginate particles (i.e., microbubbles inside alginate gel particles, called alginate microbubbles). The chemical rea...

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Detalles Bibliográficos
Autores principales: Huang, Keng-Shiang, Lin, Yung-Sheng, Chang, Wan-Ru, Wang, Yi-Ling, Yang, Chih-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269812/
https://www.ncbi.nlm.nih.gov/pubmed/23941880
http://dx.doi.org/10.3390/molecules18089594
Descripción
Sumario:Microbubble particles have been extensively utilized as temporal templates for various biomedical applications. This study proposes a facile strategy to obtain microbubble-containing alginate particles (i.e., microbubbles inside alginate gel particles, called alginate microbubbles). The chemical reaction of sodium bicarbonate and hydrogen peroxide to produce gaseous carbon dioxide and oxygen was utilized to form microbubbles within alginate particles. Uniform alginate particles were obtained by a stable needle-based droplet formation process. Kinetic reaction of gas formation was monitored for 2% alginate particles. The gas formation increased with the concentrations of sodium bicarbonate (1–5 wt%) and hydrogen peroxide (0–36.5 wt%).