Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal c...

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Autores principales: Guo, Yuh-Cherng, Chang, Che-Mai, Hsu, Wen-Li, Chiu, Siou-Jin, Tsai, Yao-Ting, Chou, Yii-Her, Hou, Ming-Feng, Wang, Jaw-Yan, Lee, Mei-Hsien, Tsai, Ke-Li, Chang, Wei-Chiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269835/
https://www.ncbi.nlm.nih.gov/pubmed/23736792
http://dx.doi.org/10.3390/molecules18066584
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author Guo, Yuh-Cherng
Chang, Che-Mai
Hsu, Wen-Li
Chiu, Siou-Jin
Tsai, Yao-Ting
Chou, Yii-Her
Hou, Ming-Feng
Wang, Jaw-Yan
Lee, Mei-Hsien
Tsai, Ke-Li
Chang, Wei-Chiao
author_facet Guo, Yuh-Cherng
Chang, Che-Mai
Hsu, Wen-Li
Chiu, Siou-Jin
Tsai, Yao-Ting
Chou, Yii-Her
Hou, Ming-Feng
Wang, Jaw-Yan
Lee, Mei-Hsien
Tsai, Ke-Li
Chang, Wei-Chiao
author_sort Guo, Yuh-Cherng
collection PubMed
description Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca(2+) influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.
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spelling pubmed-62698352018-12-17 Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization Guo, Yuh-Cherng Chang, Che-Mai Hsu, Wen-Li Chiu, Siou-Jin Tsai, Yao-Ting Chou, Yii-Her Hou, Ming-Feng Wang, Jaw-Yan Lee, Mei-Hsien Tsai, Ke-Li Chang, Wei-Chiao Molecules Article Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca(2+) influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration. MDPI 2013-06-04 /pmc/articles/PMC6269835/ /pubmed/23736792 http://dx.doi.org/10.3390/molecules18066584 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Guo, Yuh-Cherng
Chang, Che-Mai
Hsu, Wen-Li
Chiu, Siou-Jin
Tsai, Yao-Ting
Chou, Yii-Her
Hou, Ming-Feng
Wang, Jaw-Yan
Lee, Mei-Hsien
Tsai, Ke-Li
Chang, Wei-Chiao
Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
title Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
title_full Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
title_fullStr Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
title_full_unstemmed Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
title_short Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
title_sort indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269835/
https://www.ncbi.nlm.nih.gov/pubmed/23736792
http://dx.doi.org/10.3390/molecules18066584
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