Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone

The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-β-d-glucopyranoside (2a) and stigmasterol-3-O-β-d-glucopyranoside (2b), phaeophytin A (3), 17(3)-e...

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Detalles Bibliográficos
Autores principales: Chaves, Otemberg Souza, Gomes, Roosevelt Albuquerque, Tomaz, Anna Cláudia de Andrade, Fernandes, Marianne Guedes, das Graças Mendes Junior, Leônidas, de Fátima Agra, Maria, Braga, Valdir Andrade, de Fátima Vanderlei de Souza, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269840/
https://www.ncbi.nlm.nih.gov/pubmed/23455668
http://dx.doi.org/10.3390/molecules18032769
Descripción
Sumario:The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-β-d-glucopyranoside (2a) and stigmasterol-3-O-β-d-glucopyranoside (2b), phaeophytin A (3), 17(3)-ethoxypheophorbide A (4), 13(2)-hydroxy phaeophytin B (5), 17(3)-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by (1)H- and (13)C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.

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