Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone

The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-β-d-glucopyranoside (2a) and stigmasterol-3-O-β-d-glucopyranoside (2b), phaeophytin A (3), 17(3)-e...

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Autores principales: Chaves, Otemberg Souza, Gomes, Roosevelt Albuquerque, Tomaz, Anna Cláudia de Andrade, Fernandes, Marianne Guedes, das Graças Mendes Junior, Leônidas, de Fátima Agra, Maria, Braga, Valdir Andrade, de Fátima Vanderlei de Souza, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269840/
https://www.ncbi.nlm.nih.gov/pubmed/23455668
http://dx.doi.org/10.3390/molecules18032769
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author Chaves, Otemberg Souza
Gomes, Roosevelt Albuquerque
Tomaz, Anna Cláudia de Andrade
Fernandes, Marianne Guedes
das Graças Mendes Junior, Leônidas
de Fátima Agra, Maria
Braga, Valdir Andrade
de Fátima Vanderlei de Souza, Maria
author_facet Chaves, Otemberg Souza
Gomes, Roosevelt Albuquerque
Tomaz, Anna Cláudia de Andrade
Fernandes, Marianne Guedes
das Graças Mendes Junior, Leônidas
de Fátima Agra, Maria
Braga, Valdir Andrade
de Fátima Vanderlei de Souza, Maria
author_sort Chaves, Otemberg Souza
collection PubMed
description The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-β-d-glucopyranoside (2a) and stigmasterol-3-O-β-d-glucopyranoside (2b), phaeophytin A (3), 17(3)-ethoxypheophorbide A (4), 13(2)-hydroxy phaeophytin B (5), 17(3)-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by (1)H- and (13)C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.
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spelling pubmed-62698402018-12-20 Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone Chaves, Otemberg Souza Gomes, Roosevelt Albuquerque Tomaz, Anna Cláudia de Andrade Fernandes, Marianne Guedes das Graças Mendes Junior, Leônidas de Fátima Agra, Maria Braga, Valdir Andrade de Fátima Vanderlei de Souza, Maria Molecules Article The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-β-d-glucopyranoside (2a) and stigmasterol-3-O-β-d-glucopyranoside (2b), phaeophytin A (3), 17(3)-ethoxypheophorbide A (4), 13(2)-hydroxy phaeophytin B (5), 17(3)-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by (1)H- and (13)C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time. MDPI 2013-03-01 /pmc/articles/PMC6269840/ /pubmed/23455668 http://dx.doi.org/10.3390/molecules18032769 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chaves, Otemberg Souza
Gomes, Roosevelt Albuquerque
Tomaz, Anna Cláudia de Andrade
Fernandes, Marianne Guedes
das Graças Mendes Junior, Leônidas
de Fátima Agra, Maria
Braga, Valdir Andrade
de Fátima Vanderlei de Souza, Maria
Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
title Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
title_full Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
title_fullStr Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
title_full_unstemmed Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
title_short Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
title_sort secondary metabolites from sida rhombifolia l. (malvaceae) and the vasorelaxant activity of cryptolepinone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269840/
https://www.ncbi.nlm.nih.gov/pubmed/23455668
http://dx.doi.org/10.3390/molecules18032769
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