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Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases

Despite the advances in molecular biology and biochemistry, the prognosis of patients suffering from tumor diseases remains poor. The limited therapeutic success can be explained by the insufficient performance of the common chemotherapeutic drugs that lack the ability to specifically target tumor t...

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Detalles Bibliográficos
Autores principales: Jamous, Mazen, Haberkorn, Uwe, Mier, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269889/
https://www.ncbi.nlm.nih.gov/pubmed/23493103
http://dx.doi.org/10.3390/molecules18033379
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author Jamous, Mazen
Haberkorn, Uwe
Mier, Walter
author_facet Jamous, Mazen
Haberkorn, Uwe
Mier, Walter
author_sort Jamous, Mazen
collection PubMed
description Despite the advances in molecular biology and biochemistry, the prognosis of patients suffering from tumor diseases remains poor. The limited therapeutic success can be explained by the insufficient performance of the common chemotherapeutic drugs that lack the ability to specifically target tumor tissues. Recently peptide radiopharmaceuticals have been developed that enable the concurrent imaging and therapy of tumors expressing a specific target. Here, with a special emphasis on the synthesis of the building blocks required for the complexation of metallic radioisotopes, the requirements to the design and synthesis of radiolabeled peptides for clinical applications are described.
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spelling pubmed-62698892018-12-20 Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases Jamous, Mazen Haberkorn, Uwe Mier, Walter Molecules Review Despite the advances in molecular biology and biochemistry, the prognosis of patients suffering from tumor diseases remains poor. The limited therapeutic success can be explained by the insufficient performance of the common chemotherapeutic drugs that lack the ability to specifically target tumor tissues. Recently peptide radiopharmaceuticals have been developed that enable the concurrent imaging and therapy of tumors expressing a specific target. Here, with a special emphasis on the synthesis of the building blocks required for the complexation of metallic radioisotopes, the requirements to the design and synthesis of radiolabeled peptides for clinical applications are described. MDPI 2013-03-14 /pmc/articles/PMC6269889/ /pubmed/23493103 http://dx.doi.org/10.3390/molecules18033379 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Jamous, Mazen
Haberkorn, Uwe
Mier, Walter
Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases
title Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases
title_full Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases
title_fullStr Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases
title_full_unstemmed Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases
title_short Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases
title_sort synthesis of peptide radiopharmaceuticals for the therapy and diagnosis of tumor diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269889/
https://www.ncbi.nlm.nih.gov/pubmed/23493103
http://dx.doi.org/10.3390/molecules18033379
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