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The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation
This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269902/ https://www.ncbi.nlm.nih.gov/pubmed/24071989 http://dx.doi.org/10.3390/molecules181011836 |
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author | Dong, Huei-Ping Wu, Hui-Ming Chen, Sheue-Jiun Chen, Chung-Yi |
author_facet | Dong, Huei-Ping Wu, Hui-Ming Chen, Sheue-Jiun Chen, Chung-Yi |
author_sort | Dong, Huei-Ping |
collection | PubMed |
description | This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses. |
format | Online Article Text |
id | pubmed-6269902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62699022018-12-18 The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation Dong, Huei-Ping Wu, Hui-Ming Chen, Sheue-Jiun Chen, Chung-Yi Molecules Article This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses. MDPI 2013-09-25 /pmc/articles/PMC6269902/ /pubmed/24071989 http://dx.doi.org/10.3390/molecules181011836 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Dong, Huei-Ping Wu, Hui-Ming Chen, Sheue-Jiun Chen, Chung-Yi The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation |
title | The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation |
title_full | The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation |
title_fullStr | The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation |
title_full_unstemmed | The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation |
title_short | The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation |
title_sort | effect of butanolides from cinnamomum tenuifolium on platelet aggregation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269902/ https://www.ncbi.nlm.nih.gov/pubmed/24071989 http://dx.doi.org/10.3390/molecules181011836 |
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