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The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation

This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not...

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Autores principales: Dong, Huei-Ping, Wu, Hui-Ming, Chen, Sheue-Jiun, Chen, Chung-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269902/
https://www.ncbi.nlm.nih.gov/pubmed/24071989
http://dx.doi.org/10.3390/molecules181011836
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author Dong, Huei-Ping
Wu, Hui-Ming
Chen, Sheue-Jiun
Chen, Chung-Yi
author_facet Dong, Huei-Ping
Wu, Hui-Ming
Chen, Sheue-Jiun
Chen, Chung-Yi
author_sort Dong, Huei-Ping
collection PubMed
description This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses.
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spelling pubmed-62699022018-12-18 The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation Dong, Huei-Ping Wu, Hui-Ming Chen, Sheue-Jiun Chen, Chung-Yi Molecules Article This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses. MDPI 2013-09-25 /pmc/articles/PMC6269902/ /pubmed/24071989 http://dx.doi.org/10.3390/molecules181011836 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Dong, Huei-Ping
Wu, Hui-Ming
Chen, Sheue-Jiun
Chen, Chung-Yi
The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation
title The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation
title_full The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation
title_fullStr The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation
title_full_unstemmed The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation
title_short The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation
title_sort effect of butanolides from cinnamomum tenuifolium on platelet aggregation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269902/
https://www.ncbi.nlm.nih.gov/pubmed/24071989
http://dx.doi.org/10.3390/molecules181011836
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