Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and Inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice

Accumulating evidence supports a role for viruses in the pathogenesis of type 1 diabetes mellitus (T1DM). Activation of dsRNA-sensing pathways by viral dsRNA induces the production of inflammatory cytokines and chemokines that trigger beta cell apoptosis, insulitis, and autoimmune-mediated beta cell...

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Detalles Bibliográficos
Autores principales: McCall, Kelly D., Schmerr, Martin J., Thuma, Jean R., James, Calvin B. L., Courreges, Maria C., Benencia, Fabian, Malgor, Ramiro, Schwartz, Frank L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269916/
https://www.ncbi.nlm.nih.gov/pubmed/23535518
http://dx.doi.org/10.3390/molecules18043841

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