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Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H(2)L(1)–H(2)L(10)) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (...

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Autores principales: Pahontu, Elena, Fala, Valeriu, Gulea, Aurelian, Poirier, Donald, Tapcov, Victor, Rosu, Tudor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269917/
https://www.ncbi.nlm.nih.gov/pubmed/23887722
http://dx.doi.org/10.3390/molecules18088812
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author Pahontu, Elena
Fala, Valeriu
Gulea, Aurelian
Poirier, Donald
Tapcov, Victor
Rosu, Tudor
author_facet Pahontu, Elena
Fala, Valeriu
Gulea, Aurelian
Poirier, Donald
Tapcov, Victor
Rosu, Tudor
author_sort Pahontu, Elena
collection PubMed
description Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H(2)L(1)–H(2)L(10)) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C(6)H(5)). The characterization of the new formed compounds was done by (1)H-NMR, (13)C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.
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spelling pubmed-62699172018-12-18 Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity Pahontu, Elena Fala, Valeriu Gulea, Aurelian Poirier, Donald Tapcov, Victor Rosu, Tudor Molecules Article Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H(2)L(1)–H(2)L(10)) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C(6)H(5)). The characterization of the new formed compounds was done by (1)H-NMR, (13)C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities. MDPI 2013-07-24 /pmc/articles/PMC6269917/ /pubmed/23887722 http://dx.doi.org/10.3390/molecules18088812 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pahontu, Elena
Fala, Valeriu
Gulea, Aurelian
Poirier, Donald
Tapcov, Victor
Rosu, Tudor
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
title Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
title_full Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
title_fullStr Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
title_full_unstemmed Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
title_short Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity
title_sort synthesis and characterization of some new cu(ii), ni(ii) and zn(ii) complexes with salicylidene thiosemicarbazones: antibacterial, antifungal and in vitro antileukemia activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269917/
https://www.ncbi.nlm.nih.gov/pubmed/23887722
http://dx.doi.org/10.3390/molecules18088812
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