Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity

New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtaine...

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Autores principales: Ignat (Grozav), Adriana, Gaina, Luiza, Kuete, Victor, Silaghi-Dumitrescu, Luminita, Efferth, Thomas, Zaharia, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269919/
https://www.ncbi.nlm.nih.gov/pubmed/23603950
http://dx.doi.org/10.3390/molecules18044679
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author Ignat (Grozav), Adriana
Gaina, Luiza
Kuete, Victor
Silaghi-Dumitrescu, Luminita
Efferth, Thomas
Zaharia, Valentin
author_facet Ignat (Grozav), Adriana
Gaina, Luiza
Kuete, Victor
Silaghi-Dumitrescu, Luminita
Efferth, Thomas
Zaharia, Valentin
author_sort Ignat (Grozav), Adriana
collection PubMed
description New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
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spelling pubmed-62699192018-12-14 Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity Ignat (Grozav), Adriana Gaina, Luiza Kuete, Victor Silaghi-Dumitrescu, Luminita Efferth, Thomas Zaharia, Valentin Molecules Article New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG). MDPI 2013-04-19 /pmc/articles/PMC6269919/ /pubmed/23603950 http://dx.doi.org/10.3390/molecules18044679 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ignat (Grozav), Adriana
Gaina, Luiza
Kuete, Victor
Silaghi-Dumitrescu, Luminita
Efferth, Thomas
Zaharia, Valentin
Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
title Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
title_full Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
title_fullStr Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
title_full_unstemmed Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
title_short Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
title_sort microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269919/
https://www.ncbi.nlm.nih.gov/pubmed/23603950
http://dx.doi.org/10.3390/molecules18044679
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