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Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)

Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochro...

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Autores principales: Lu, Keyang, Zhang, Yisheng, Li, Li, Wang, Xuewei, Ding, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269930/
https://www.ncbi.nlm.nih.gov/pubmed/24013408
http://dx.doi.org/10.3390/molecules180910944
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author Lu, Keyang
Zhang, Yisheng
Li, Li
Wang, Xuewei
Ding, Gang
author_facet Lu, Keyang
Zhang, Yisheng
Li, Li
Wang, Xuewei
Ding, Gang
author_sort Lu, Keyang
collection PubMed
description Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quél. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected.
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spelling pubmed-62699302018-12-18 Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68) Lu, Keyang Zhang, Yisheng Li, Li Wang, Xuewei Ding, Gang Molecules Article Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quél. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected. MDPI 2013-09-05 /pmc/articles/PMC6269930/ /pubmed/24013408 http://dx.doi.org/10.3390/molecules180910944 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lu, Keyang
Zhang, Yisheng
Li, Li
Wang, Xuewei
Ding, Gang
Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
title Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
title_full Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
title_fullStr Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
title_full_unstemmed Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
title_short Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
title_sort chaetochromones a and b, two new polyketides from the fungus chaetomium indicum (cbs.860.68)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269930/
https://www.ncbi.nlm.nih.gov/pubmed/24013408
http://dx.doi.org/10.3390/molecules180910944
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