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Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68)
Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269930/ https://www.ncbi.nlm.nih.gov/pubmed/24013408 http://dx.doi.org/10.3390/molecules180910944 |
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author | Lu, Keyang Zhang, Yisheng Li, Li Wang, Xuewei Ding, Gang |
author_facet | Lu, Keyang Zhang, Yisheng Li, Li Wang, Xuewei Ding, Gang |
author_sort | Lu, Keyang |
collection | PubMed |
description | Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quél. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected. |
format | Online Article Text |
id | pubmed-6269930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62699302018-12-18 Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68) Lu, Keyang Zhang, Yisheng Li, Li Wang, Xuewei Ding, Gang Molecules Article Chaetochromones A (1) and B (2), two novel polyketides, were isolated from the crude extract of fungus Chaetomium indicum (CBS.860.68) together with three known analogues PI-3(3), PI-4 (4) and SB236050 (5). The structures of these compounds were determined by HRESI-MS and NMR experiments. Chaetochromones A (1) and B (2) are a member of the polyketides family, which might originate from a similar biogenetic pathway as the known compounds PI-3 (3), PI-4 (4) and SB236050 (5). The biological activities of these secondary metabolites were evaluated against eight plant pathogens, including Alternaria alternata, Ilyonectria radicicola, Trichoderma viride pers, Aspergillus niger, Fusarium verticillioide, Irpex lacteus (Fr.), Poria placenta (Fr.) Cooke and Coriolus versicolor (L.) Quél. Compound 1 displayed moderate inhibitory rate (>60%) against the brown rot fungus Poria placenta (Fr.) Cooke, which causes significant wood decay. In addition, the cytotoxic activities against three cancer cell lines A549, MDA-MB-231, PANC-1 were also tested, without any inhibitory activities being detected. MDPI 2013-09-05 /pmc/articles/PMC6269930/ /pubmed/24013408 http://dx.doi.org/10.3390/molecules180910944 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Lu, Keyang Zhang, Yisheng Li, Li Wang, Xuewei Ding, Gang Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium indicum (CBS.860.68) |
title | Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium
indicum (CBS.860.68) |
title_full | Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium
indicum (CBS.860.68) |
title_fullStr | Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium
indicum (CBS.860.68) |
title_full_unstemmed | Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium
indicum (CBS.860.68) |
title_short | Chaetochromones A and B, Two New Polyketides from the Fungus Chaetomium
indicum (CBS.860.68) |
title_sort | chaetochromones a and b, two new polyketides from the fungus chaetomium
indicum (cbs.860.68) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269930/ https://www.ncbi.nlm.nih.gov/pubmed/24013408 http://dx.doi.org/10.3390/molecules180910944 |
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