Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke

Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 1–4) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analy...

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Autores principales: Tian, Xinhui, Ding, Gang, Peng, Chaozhong, Hu, Yanbao, Li, Li, Chen, Hong, Zou, Zhongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269932/
https://www.ncbi.nlm.nih.gov/pubmed/23434858
http://dx.doi.org/10.3390/molecules18021720
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author Tian, Xinhui
Ding, Gang
Peng, Chaozhong
Hu, Yanbao
Li, Li
Chen, Hong
Zou, Zhongmei
author_facet Tian, Xinhui
Ding, Gang
Peng, Chaozhong
Hu, Yanbao
Li, Li
Chen, Hong
Zou, Zhongmei
author_sort Tian, Xinhui
collection PubMed
description Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 1–4) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 1–3 showed moderate cytotoxity against HeLa cells, with IC(50) values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala.
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spelling pubmed-62699322018-12-14 Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke Tian, Xinhui Ding, Gang Peng, Chaozhong Hu, Yanbao Li, Li Chen, Hong Zou, Zhongmei Molecules Article Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 1–4) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 1–3 showed moderate cytotoxity against HeLa cells, with IC(50) values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala. MDPI 2013-01-29 /pmc/articles/PMC6269932/ /pubmed/23434858 http://dx.doi.org/10.3390/molecules18021720 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tian, Xinhui
Ding, Gang
Peng, Chaozhong
Hu, Yanbao
Li, Li
Chen, Hong
Zou, Zhongmei
Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke
title Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke
title_full Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke
title_fullStr Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke
title_full_unstemmed Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke
title_short Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke
title_sort sinapyl alcohol derivatives from the lipo-soluble part of dichrocephala benthamii c. b. clarke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269932/
https://www.ncbi.nlm.nih.gov/pubmed/23434858
http://dx.doi.org/10.3390/molecules18021720
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