Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environ...

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Detalles Bibliográficos
Autores principales: Dou, Guolan, Xu, Pan, Li, Qiang, Xi, Yukun, Huang, Zhibin, Shi, Daqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269935/
https://www.ncbi.nlm.nih.gov/pubmed/24196411
http://dx.doi.org/10.3390/molecules181113645
Descripción
Sumario:A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.

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