Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environ...

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Detalles Bibliográficos
Autores principales: Dou, Guolan, Xu, Pan, Li, Qiang, Xi, Yukun, Huang, Zhibin, Shi, Daqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269935/
https://www.ncbi.nlm.nih.gov/pubmed/24196411
http://dx.doi.org/10.3390/molecules181113645
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author Dou, Guolan
Xu, Pan
Li, Qiang
Xi, Yukun
Huang, Zhibin
Shi, Daqing
author_facet Dou, Guolan
Xu, Pan
Li, Qiang
Xi, Yukun
Huang, Zhibin
Shi, Daqing
author_sort Dou, Guolan
collection PubMed
description A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.
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spelling pubmed-62699352018-12-20 Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media Dou, Guolan Xu, Pan Li, Qiang Xi, Yukun Huang, Zhibin Shi, Daqing Molecules Article A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure. MDPI 2013-11-05 /pmc/articles/PMC6269935/ /pubmed/24196411 http://dx.doi.org/10.3390/molecules181113645 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Dou, Guolan
Xu, Pan
Li, Qiang
Xi, Yukun
Huang, Zhibin
Shi, Daqing
Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media
title Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media
title_full Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media
title_fullStr Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media
title_full_unstemmed Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media
title_short Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media
title_sort clean and efficient synthesis of isoxazole derivatives in aqueous media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269935/
https://www.ncbi.nlm.nih.gov/pubmed/24196411
http://dx.doi.org/10.3390/molecules181113645
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AT xiyukun cleanandefficientsynthesisofisoxazolederivativesinaqueousmedia
AT huangzhibin cleanandefficientsynthesisofisoxazolederivativesinaqueousmedia
AT shidaqing cleanandefficientsynthesisofisoxazolederivativesinaqueousmedia

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