Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity

Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1–3 and five known analogues 4–8. Structural elucidations of 1–3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high reso...

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Autores principales: Wu, Yu-Ping, Zhao, Wei, Xia, Zhen-Yuan, Kong, Guang-Hui, Lu, Xiu-Ping, Hu, Qiu-Fen, Gao, Xue-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269950/
https://www.ncbi.nlm.nih.gov/pubmed/23945641
http://dx.doi.org/10.3390/molecules18089663
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author Wu, Yu-Ping
Zhao, Wei
Xia, Zhen-Yuan
Kong, Guang-Hui
Lu, Xiu-Ping
Hu, Qiu-Fen
Gao, Xue-Mei
author_facet Wu, Yu-Ping
Zhao, Wei
Xia, Zhen-Yuan
Kong, Guang-Hui
Lu, Xiu-Ping
Hu, Qiu-Fen
Gao, Xue-Mei
author_sort Wu, Yu-Ping
collection PubMed
description Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1–3 and five known analogues 4–8. Structural elucidations of 1–3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1–3 showed anti-TMV activities, with inhibition rates above 20%, especially for 1, which had a lower IC(50) value of 21.4 µM.
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spelling pubmed-62699502018-12-18 Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity Wu, Yu-Ping Zhao, Wei Xia, Zhen-Yuan Kong, Guang-Hui Lu, Xiu-Ping Hu, Qiu-Fen Gao, Xue-Mei Molecules Article Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1–3 and five known analogues 4–8. Structural elucidations of 1–3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1–3 showed anti-TMV activities, with inhibition rates above 20%, especially for 1, which had a lower IC(50) value of 21.4 µM. MDPI 2013-08-13 /pmc/articles/PMC6269950/ /pubmed/23945641 http://dx.doi.org/10.3390/molecules18089663 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Yu-Ping
Zhao, Wei
Xia, Zhen-Yuan
Kong, Guang-Hui
Lu, Xiu-Ping
Hu, Qiu-Fen
Gao, Xue-Mei
Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity
title Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity
title_full Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity
title_fullStr Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity
title_full_unstemmed Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity
title_short Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity
title_sort three novel xanthones from garcinia paucinervis and their anti-tmv activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269950/
https://www.ncbi.nlm.nih.gov/pubmed/23945641
http://dx.doi.org/10.3390/molecules18089663
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