Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti...

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Autores principales: Lin, Yu-Fang, Kuo, Chao-Ying, Wen, Zhi-Hong, Lin, Yen-You, Wang, Wei-Hsien, Su, Jui-Hsin, Sheu, Jyh-Horng, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269975/
https://www.ncbi.nlm.nih.gov/pubmed/23846756
http://dx.doi.org/10.3390/molecules18078160
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author Lin, Yu-Fang
Kuo, Chao-Ying
Wen, Zhi-Hong
Lin, Yen-You
Wang, Wei-Hsien
Su, Jui-Hsin
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_facet Lin, Yu-Fang
Kuo, Chao-Ying
Wen, Zhi-Hong
Lin, Yen-You
Wang, Wei-Hsien
Su, Jui-Hsin
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_sort Lin, Yu-Fang
collection PubMed
description A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.
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spelling pubmed-62699752018-12-17 Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis Lin, Yu-Fang Kuo, Chao-Ying Wen, Zhi-Hong Lin, Yen-You Wang, Wei-Hsien Su, Jui-Hsin Sheu, Jyh-Horng Sung, Ping-Jyun Molecules Article A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells. MDPI 2013-07-10 /pmc/articles/PMC6269975/ /pubmed/23846756 http://dx.doi.org/10.3390/molecules18078160 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lin, Yu-Fang
Kuo, Chao-Ying
Wen, Zhi-Hong
Lin, Yen-You
Wang, Wei-Hsien
Su, Jui-Hsin
Sheu, Jyh-Horng
Sung, Ping-Jyun
Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis
title Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis
title_full Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis
title_fullStr Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis
title_full_unstemmed Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis
title_short Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis
title_sort flexibilisquinone, a new anti-inflammatory quinone from the cultured soft coral sinularia flexibilis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269975/
https://www.ncbi.nlm.nih.gov/pubmed/23846756
http://dx.doi.org/10.3390/molecules18078160
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