Cargando…
Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthe...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269998/ https://www.ncbi.nlm.nih.gov/pubmed/24352013 http://dx.doi.org/10.3390/molecules181215541 |
_version_ | 1783376597055700992 |
---|---|
author | Secci, Francesco Frongia, Angelo Piras, Pier Paolo |
author_facet | Secci, Francesco Frongia, Angelo Piras, Pier Paolo |
author_sort | Secci, Francesco |
collection | PubMed |
description | In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000–2013. |
format | Online Article Text |
id | pubmed-6269998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62699982018-12-20 Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones Secci, Francesco Frongia, Angelo Piras, Pier Paolo Molecules Review In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000–2013. MDPI 2013-12-13 /pmc/articles/PMC6269998/ /pubmed/24352013 http://dx.doi.org/10.3390/molecules181215541 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Secci, Francesco Frongia, Angelo Piras, Pier Paolo Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones |
title | Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones |
title_full | Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones |
title_fullStr | Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones |
title_full_unstemmed | Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones |
title_short | Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones |
title_sort | stereocontrolled synthesis and functionalization of cyclobutanes and cyclobutanones |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269998/ https://www.ncbi.nlm.nih.gov/pubmed/24352013 http://dx.doi.org/10.3390/molecules181215541 |
work_keys_str_mv | AT seccifrancesco stereocontrolledsynthesisandfunctionalizationofcyclobutanesandcyclobutanones AT frongiaangelo stereocontrolledsynthesisandfunctionalizationofcyclobutanesandcyclobutanones AT piraspierpaolo stereocontrolledsynthesisandfunctionalizationofcyclobutanesandcyclobutanones |