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Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones

In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthe...

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Autores principales: Secci, Francesco, Frongia, Angelo, Piras, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269998/
https://www.ncbi.nlm.nih.gov/pubmed/24352013
http://dx.doi.org/10.3390/molecules181215541
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author Secci, Francesco
Frongia, Angelo
Piras, Pier Paolo
author_facet Secci, Francesco
Frongia, Angelo
Piras, Pier Paolo
author_sort Secci, Francesco
collection PubMed
description In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000–2013.
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spelling pubmed-62699982018-12-20 Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones Secci, Francesco Frongia, Angelo Piras, Pier Paolo Molecules Review In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000–2013. MDPI 2013-12-13 /pmc/articles/PMC6269998/ /pubmed/24352013 http://dx.doi.org/10.3390/molecules181215541 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Secci, Francesco
Frongia, Angelo
Piras, Pier Paolo
Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
title Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
title_full Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
title_fullStr Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
title_full_unstemmed Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
title_short Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
title_sort stereocontrolled synthesis and functionalization of cyclobutanes and cyclobutanones
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269998/
https://www.ncbi.nlm.nih.gov/pubmed/24352013
http://dx.doi.org/10.3390/molecules181215541
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