Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs

A facile three step synthesis of a group of N(1),N(5)-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N(1),N(5)-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N(1),N(5)-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These products are designed to function...

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Autores principales: Kode, Nageswara Rao, Vanden Eynde, Jean J., Mayence, Annie, Wang, Guangdi, Huang, Tien L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270005/
https://www.ncbi.nlm.nih.gov/pubmed/24036514
http://dx.doi.org/10.3390/molecules180911250
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author Kode, Nageswara Rao
Vanden Eynde, Jean J.
Mayence, Annie
Wang, Guangdi
Huang, Tien L.
author_facet Kode, Nageswara Rao
Vanden Eynde, Jean J.
Mayence, Annie
Wang, Guangdi
Huang, Tien L.
author_sort Kode, Nageswara Rao
collection PubMed
description A facile three step synthesis of a group of N(1),N(5)-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N(1),N(5)-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N(1),N(5)-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These products are designed to function as masked bis-amidine prodrugs of a promising N(1),N(5)-bis[4-(N'-(carbamimidoyl)phenyl]glutaramide antifungal lead.
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spelling pubmed-62700052018-12-18 Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs Kode, Nageswara Rao Vanden Eynde, Jean J. Mayence, Annie Wang, Guangdi Huang, Tien L. Molecules Article A facile three step synthesis of a group of N(1),N(5)-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N(1),N(5)-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N(1),N(5)-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These products are designed to function as masked bis-amidine prodrugs of a promising N(1),N(5)-bis[4-(N'-(carbamimidoyl)phenyl]glutaramide antifungal lead. MDPI 2013-09-12 /pmc/articles/PMC6270005/ /pubmed/24036514 http://dx.doi.org/10.3390/molecules180911250 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kode, Nageswara Rao
Vanden Eynde, Jean J.
Mayence, Annie
Wang, Guangdi
Huang, Tien L.
Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs
title Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs
title_full Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs
title_fullStr Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs
title_full_unstemmed Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs
title_short Design and Synthesis of N(1),N(5)-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs
title_sort design and synthesis of n(1),n(5)-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270005/
https://www.ncbi.nlm.nih.gov/pubmed/24036514
http://dx.doi.org/10.3390/molecules180911250
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