Cargando…

An Improved HPLC Method with the Aid of a Chemometric Protocol: Simultaneous Determination of Atorvastatin and Its Metabolites in Plasma

The aim of the present study was to optimize a chromatographic method for the analysis of atorvastatin (acid and lactone forms), ortho- and para-hydroxyatorvastatin by using an experimental design approach. Optimization experiments were conducted through a process of screening and optimization. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crevar-Sakač, Milkica, Vujić, Zorica, Brborić, Jasmina, Kuntić, Vesna, Uskoković-Marković, Snežana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270013/ https://www.ncbi.nlm.nih.gov/pubmed/23439563 http://dx.doi.org/10.3390/molecules18032469

Ejemplares similares

Simultaneous Analysis of Irbesartan and Hydrochlorothiazide: An Improved HPLC Method with the Aid of a Chemometric Protocol
por: Vujić, Zorica, et al.
Publicado: (2012)

Effects of Rutin and Hesperidin and their Al(III) and Cu(II) Complexes on in Vitro Plasma Coagulation Assays
por: Kuntić, Vesna, et al.
Publicado: (2011)

The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet
por: Bogavac-Stanojevic, Natasa, et al.
Publicado: (2018)

Simultaneous Determination of Preservatives in Dairy Products by HPLC and Chemometric Analysis
por: Zamani Mazdeh, Fatemeh, et al.
Publicado: (2017)

Screening and Analysis of the Marker Components in Ganoderma lucidum by HPLC and HPLC-MS(n) with the Aid of Chemometrics
por: Wu, Lingfang, et al.
Publicado: (2017)

Development of a new HPLC method for simultaneous determination of clopidogrel and its major metabolite using a chemometric approach
por: ANUTA, V., et al.
Publicado: (2015)

Development of Validated Bioanalytical HPLC-UV Method for Simultaneous Estimation of Amlodipine and Atorvastatin in Rat Plasma
por: Talele, G. S., et al.
Publicado: (2015)

Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study
por: Croitoru, Octavian, et al.
Publicado: (2015)

Simultaneous Analysis of Clopidogrel Bisulfate, Acetylsalicylic Acid and Atorvastatin calcium in Tablets by HPLC Method
por: SPIRIDON, A.M., et al.
Publicado: (2015)

Screening and Analysis of the Potential Bioactive Components of Poria cocos (Schw.) Wolf by HPLC and HPLC-MS(n) with the Aid of Chemometrics
por: Wu, Ling-Fang, et al.
Publicado: (2016)

HPLC-Based Chemometric Analysis for Coffee Adulteration
por: Cheah, Wai Lok, et al.
Publicado: (2020)

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms
por: Jain, N., et al.
Publicado: (2008)

Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Binary Mixture by Spectrofluorimetry and HPLC Coupled with Fluorescence Detection
por: Moussa, Bahia A., et al.
Publicado: (2013)

Preparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma
por: Han, Jun-ping, et al.
Publicado: (2019)

Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey
por: Zhang, Xiao-Hua, et al.
Publicado: (2023)

New Chemometrics Mode Based on Adjacent Data Points’ Differences for the Simultaneous Determination of Clopidogrel, Atorvastatin, and Aspirin in their Combined Ternary Drug Formulation
por: Nejem, R’afat Mahmoud, et al.
Publicado: (2014)

Development and Validation of a Reversed-phase HPLC Method for Simultaneous Determination of Aspirin, Atorvastatin Calcium and Clopidogrel Bisulphate in Capsules
por: Londhe, S. V., et al.
Publicado: (2011)

Classification of Hen Eggs by HPLC-UV Fingerprinting and Chemometric Methods
por: Campmajó, Guillem, et al.
Publicado: (2019)

Chemometrics-Assisted UV Spectrophotometric and RP-HPLC Methods for the Simultaneous Determination of Tolperisone Hydrochloride and Diclofenac Sodium in their Combined Pharmaceutical Formulation
por: Gohel, Nikunj Rameshbhai, et al.
Publicado: (2013)

Micellar eco-friendly HPLC method for simultaneous analysis of ternary combination of aspirin, atorvastatin and ramipril: application to content uniformity testing
por: Abdallah, Nora A., et al.
Publicado: (2023)

Simultaneous quantitation of atorvastatin and its two active metabolites in human plasma by liquid chromatography/(–) electrospray tandem mass spectrometry
por: Partani, Pankaj, et al.
Publicado: (2014)

Degradation Kinetics of Atorvastatin under Stress Conditions and Chemical Analysis by HPLC
por: Oliveira, Marcelo Antonio, et al.
Publicado: (2013)

Stability Indicating RP-HPLC Method for the Simultaneous Determination of Atorvastatin Calcium, Metformin Hydrochloride, and Glimepiride in Bulk and Combined Tablet Dosage Form
por: Ramesh, Devi, et al.
Publicado: (2014)

A Fast and Validated Reversed-Phase HPLC Method for Simultaneous Determination of Simvastatin, Atorvastatin, Telmisartan and Irbesartan in Bulk Drugs and Tablet Formulations
por: Alhazmi, Hassan A., et al.
Publicado: (2017)

Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection—Protocol Optimization and Pitfalls
por: Vujacic-Mirski, Ksenija, et al.
Publicado: (2022)

Using Chemometric Analyses for Tracing the Regional Origin of Multifloral Honeys of Montenegro
por: Vukašinović-Pešić, Vesna, et al.
Publicado: (2020)

Development and validation of a rapid HPLC- fluorescence method for simultaneous determination of venlafaxine and its major metabolites in human plasma
por: Ardakani, Y. H., et al.
Publicado: (2010)

HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations
por: Hawrył, Anna, et al.
Publicado: (2020)

Classification of Andrographis paniculata extracts by solvent extraction using HPLC fingerprint and chemometric analysis
por: Rafi, M., et al.
Publicado: (2020)

HPLC/DAD, Antibacterial and Antioxidant Activities of Plectranthus Species (Lamiaceae) Combined with the Chemometric Calculations
por: Rodrigues, Fabíola F. G., et al.
Publicado: (2021)

Gender Discrimination of Flower Buds of Mature Populus tomentosa by HPLC Fingerprint Combined with Chemometrics
por: Li, Zhuojun, et al.
Publicado: (2022)

Targeted HPLC-UV Polyphenolic Profiling to Detect and Quantify Adulterated Tea Samples by Chemometrics
por: Romers, Thom, et al.
Publicado: (2023)

Stability Indicating RP-HPLC Estimation of Atorvastatin Calcium and Amlodipine Besylate in Pharmaceutical Formulations
por: Shah, D. A., et al.
Publicado: (2008)

HPLC-DAD Method for the Pharmacokinetic Interaction Study of Atorvastatin with Pioglitazone and Cholestyramine in Wistar Rats
por: Sharma, Ritesh N, et al.
Publicado: (2014)

Quality Evaluation and Chemical Markers Screening of Salvia miltiorrhiza Bge. (Danshen) Based on HPLC Fingerprints and HPLC-MS(n) Coupled with Chemometrics
por: Liang, Wenyi, et al.
Publicado: (2017)

Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study
por: Gao, Sijia, et al.
Publicado: (2019)

Application of Ionic Liquids as Mobile Phase Additives for Simultaneous Analysis of Nicotine and Its Metabolite Cotinine in Human Plasma by HPLC–DAD
por: Axente, Roxana E., et al.
Publicado: (2023)

Simultaneous determination of mometasone furoate and calcipotriol in a binary mixture by validated HPLC and chemometric-assisted UV spectrophotometric methods and identification of degradation products by LC-MS
por: Jahani, Maryam, et al.
Publicado: (2023)

Development of an RP-HPLC-UV Method for Simultaneous Detection of Nimodipine and its Metabolite in Cerebrospinal Fluid of Rat
por: Sotoudegan, Farzaneh, et al.
Publicado: (2017)

Chemometric Analyses for the Characterization of Raw and Stir-Frying Processed Drynariae Rhizoma Based on HPLC Fingerprints
por: Hu, Jing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5u6akoa0tp7t0vrpp8tfqd05es