Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.

A new pregnane steroid, 1, and three known analogues 2–4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by appli...

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Detalles Bibliográficos
Autores principales: Zhao, Hong-Ying, Shao, Chang-Lun, Li, Zhi-Yong, Han, Lei, Cao, Fei, Wang, Chang-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270022/
https://www.ncbi.nlm.nih.gov/pubmed/23503119
http://dx.doi.org/10.3390/molecules18033458
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author Zhao, Hong-Ying
Shao, Chang-Lun
Li, Zhi-Yong
Han, Lei
Cao, Fei
Wang, Chang-Yun
author_facet Zhao, Hong-Ying
Shao, Chang-Lun
Li, Zhi-Yong
Han, Lei
Cao, Fei
Wang, Chang-Yun
author_sort Zhao, Hong-Ying
collection PubMed
description A new pregnane steroid, 1, and three known analogues 2–4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC(50) values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM).
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spelling pubmed-62700222018-12-20 Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp. Zhao, Hong-Ying Shao, Chang-Lun Li, Zhi-Yong Han, Lei Cao, Fei Wang, Chang-Yun Molecules Article A new pregnane steroid, 1, and three known analogues 2–4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC(50) values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM). MDPI 2013-03-15 /pmc/articles/PMC6270022/ /pubmed/23503119 http://dx.doi.org/10.3390/molecules18033458 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhao, Hong-Ying
Shao, Chang-Lun
Li, Zhi-Yong
Han, Lei
Cao, Fei
Wang, Chang-Yun
Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
title Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
title_full Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
title_fullStr Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
title_full_unstemmed Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
title_short Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
title_sort bioactive pregnane steroids from a south china sea gorgonian carijoa sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270022/
https://www.ncbi.nlm.nih.gov/pubmed/23503119
http://dx.doi.org/10.3390/molecules18033458
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