Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment

A fluorescent and colorimetric molecular probe containing phenol groups has been designed and synthesized. The anion binding ability was evaluated for biolgically important anions (F(−), Cl(−), Br(−), I(−), AcO(−) and H(2)PO(4)(−)) by theoretical investigation, UV-Vis and fluorescence spectroscopy a...

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Autores principales: Shang, Xuefang, Wang, Yingling, Wei, Xiaofang, Fu, Zhiyuan, Zhang, Jinlian, Xu, Xiufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270029/
https://www.ncbi.nlm.nih.gov/pubmed/24300118
http://dx.doi.org/10.3390/molecules181214840
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author Shang, Xuefang
Wang, Yingling
Wei, Xiaofang
Fu, Zhiyuan
Zhang, Jinlian
Xu, Xiufang
author_facet Shang, Xuefang
Wang, Yingling
Wei, Xiaofang
Fu, Zhiyuan
Zhang, Jinlian
Xu, Xiufang
author_sort Shang, Xuefang
collection PubMed
description A fluorescent and colorimetric molecular probe containing phenol groups has been designed and synthesized. The anion binding ability was evaluated for biolgically important anions (F(−), Cl(−), Br(−), I(−), AcO(−) and H(2)PO(4)(−)) by theoretical investigation, UV-Vis and fluorescence spectroscopy and (1)H-NMR titration experiments. Results indicated the probe showed strong binding ability for H(2)PO(4)(−) without the interference of other anions tested and the interaction process was accompanied by color changes. Theoretical investigation analysis revealed that intramolecular hydrogen bonds existed in the structure of the probe and the roles of molecular frontier orbitals in molecular interplay were determined.
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spelling pubmed-62700292018-12-20 Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment Shang, Xuefang Wang, Yingling Wei, Xiaofang Fu, Zhiyuan Zhang, Jinlian Xu, Xiufang Molecules Article A fluorescent and colorimetric molecular probe containing phenol groups has been designed and synthesized. The anion binding ability was evaluated for biolgically important anions (F(−), Cl(−), Br(−), I(−), AcO(−) and H(2)PO(4)(−)) by theoretical investigation, UV-Vis and fluorescence spectroscopy and (1)H-NMR titration experiments. Results indicated the probe showed strong binding ability for H(2)PO(4)(−) without the interference of other anions tested and the interaction process was accompanied by color changes. Theoretical investigation analysis revealed that intramolecular hydrogen bonds existed in the structure of the probe and the roles of molecular frontier orbitals in molecular interplay were determined. MDPI 2013-12-03 /pmc/articles/PMC6270029/ /pubmed/24300118 http://dx.doi.org/10.3390/molecules181214840 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shang, Xuefang
Wang, Yingling
Wei, Xiaofang
Fu, Zhiyuan
Zhang, Jinlian
Xu, Xiufang
Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment
title Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment
title_full Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment
title_fullStr Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment
title_full_unstemmed Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment
title_short Synthesis and Binding Ability of Molecular Probes Based on a Phenanthroline Derivative: Theory and Experiment
title_sort synthesis and binding ability of molecular probes based on a phenanthroline derivative: theory and experiment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270029/
https://www.ncbi.nlm.nih.gov/pubmed/24300118
http://dx.doi.org/10.3390/molecules181214840
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