Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum’s acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Xiaoxing, Dou, Guolan, Wang, Deming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270030/
https://www.ncbi.nlm.nih.gov/pubmed/24284481
http://dx.doi.org/10.3390/molecules181113139
_version_ 1783376604321284096
author Zhong, Xiaoxing
Dou, Guolan
Wang, Deming
author_facet Zhong, Xiaoxing
Dou, Guolan
Wang, Deming
author_sort Zhong, Xiaoxing
collection PubMed
description A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum’s acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.
format Online
Article
Text
id pubmed-6270030
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62700302018-12-20 Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives Zhong, Xiaoxing Dou, Guolan Wang, Deming Molecules Article A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum’s acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly. MDPI 2013-10-24 /pmc/articles/PMC6270030/ /pubmed/24284481 http://dx.doi.org/10.3390/molecules181113139 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhong, Xiaoxing
Dou, Guolan
Wang, Deming
Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
title Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
title_full Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
title_fullStr Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
title_full_unstemmed Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
title_short Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
title_sort polyethylene glycol (peg-400): an efficient and recyclable reaction medium for the synthesis of pyrazolo[3,4-b]pyridin-6(7h)-one derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270030/
https://www.ncbi.nlm.nih.gov/pubmed/24284481
http://dx.doi.org/10.3390/molecules181113139
work_keys_str_mv AT zhongxiaoxing polyethyleneglycolpeg400anefficientandrecyclablereactionmediumforthesynthesisofpyrazolo34bpyridin67honederivatives
AT douguolan polyethyleneglycolpeg400anefficientandrecyclablereactionmediumforthesynthesisofpyrazolo34bpyridin67honederivatives
AT wangdeming polyethyleneglycolpeg400anefficientandrecyclablereactionmediumforthesynthesisofpyrazolo34bpyridin67honederivatives

Ejemplares similares