Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates

Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by (1)H-NMR, (13)C-NMR, IR spectra, and MS (HRE...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Han, Zheng, Pengcheng, Tang, Chenghao, Xie, Ying, Wu, Fang, Song, Jie, Zhao, Jun, Li, Zhining, Li, Meichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270053/
https://www.ncbi.nlm.nih.gov/pubmed/24192914
http://dx.doi.org/10.3390/molecules181113623
_version_ 1783376609446723584
author Xiao, Han
Zheng, Pengcheng
Tang, Chenghao
Xie, Ying
Wu, Fang
Song, Jie
Zhao, Jun
Li, Zhining
Li, Meichuan
author_facet Xiao, Han
Zheng, Pengcheng
Tang, Chenghao
Xie, Ying
Wu, Fang
Song, Jie
Zhao, Jun
Li, Zhining
Li, Meichuan
author_sort Xiao, Han
collection PubMed
description Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by (1)H-NMR, (13)C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.
format Online
Article
Text
id pubmed-6270053
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62700532018-12-20 Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates Xiao, Han Zheng, Pengcheng Tang, Chenghao Xie, Ying Wu, Fang Song, Jie Zhao, Jun Li, Zhining Li, Meichuan Molecules Article Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by (1)H-NMR, (13)C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds 5i and 5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL. MDPI 2013-11-04 /pmc/articles/PMC6270053/ /pubmed/24192914 http://dx.doi.org/10.3390/molecules181113623 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xiao, Han
Zheng, Pengcheng
Tang, Chenghao
Xie, Ying
Wu, Fang
Song, Jie
Zhao, Jun
Li, Zhining
Li, Meichuan
Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates
title Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates
title_full Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates
title_fullStr Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates
title_full_unstemmed Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates
title_short Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates
title_sort synthesis and anti-tmv activity of dialkyl/dibenzyl 2-((6-substituted-benzo[d]thiazol-2-ylamino)(benzofuran-2-yl)methyl) malonates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270053/
https://www.ncbi.nlm.nih.gov/pubmed/24192914
http://dx.doi.org/10.3390/molecules181113623
work_keys_str_mv AT xiaohan synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT zhengpengcheng synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT tangchenghao synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT xieying synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT wufang synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT songjie synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT zhaojun synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT lizhining synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates
AT limeichuan synthesisandantitmvactivityofdialkyldibenzyl26substitutedbenzodthiazol2ylaminobenzofuran2ylmethylmalonates

Ejemplares similares