Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters

In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds were confirmed by MS, HRMS, (1)H-NMR and (13)C-NMR. Preliminary studies based on means o...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Hanqing, Zhou, Minjie, Duan, Lifeng, Wang, Wei, Zhang, Jianjun, Wang, Daoquan, Liang, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270060/
https://www.ncbi.nlm.nih.gov/pubmed/23519202
http://dx.doi.org/10.3390/molecules18033615
Descripción
Sumario:In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds were confirmed by MS, HRMS, (1)H-NMR and (13)C-NMR. Preliminary studies based on means of the Elson-Morgan method indicated that many compounds exhibited some inhibitory activity of glucosamine-6-phosphate synthase (GlmS), and the original fungicidal activities results showed that some of the compounds exhibited good fungicidal activities towards Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn and Botrytis cinerea Pers at the concentration of 50 µg/mL. These compounds would thus merit further study and development as antifungal agents.

Ejemplares similares