Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate

We describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its reductive coupling reactions under mild conditions with unprotected thiouridine and glutathione. Selenosulfide products such as these comprise reversibly conjugated bio-compo...

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Detalles Bibliográficos
Autores principales: Abdo, Mohannad, Sun, Zhexun, Knapp, Spencer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270073/
https://www.ncbi.nlm.nih.gov/pubmed/23381022
http://dx.doi.org/10.3390/molecules18021963
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author Abdo, Mohannad
Sun, Zhexun
Knapp, Spencer
author_facet Abdo, Mohannad
Sun, Zhexun
Knapp, Spencer
author_sort Abdo, Mohannad
collection PubMed
description We describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its reductive coupling reactions under mild conditions with unprotected thiouridine and glutathione. Selenosulfide products such as these comprise reversibly conjugated bio-components, and can potentially find uses as probes of biological function, such as enzyme inhibitors, delivery systems, or structural mimics.
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spelling pubmed-62700732018-12-14 Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate Abdo, Mohannad Sun, Zhexun Knapp, Spencer Molecules Article We describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its reductive coupling reactions under mild conditions with unprotected thiouridine and glutathione. Selenosulfide products such as these comprise reversibly conjugated bio-components, and can potentially find uses as probes of biological function, such as enzyme inhibitors, delivery systems, or structural mimics. MDPI 2013-02-04 /pmc/articles/PMC6270073/ /pubmed/23381022 http://dx.doi.org/10.3390/molecules18021963 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Abdo, Mohannad
Sun, Zhexun
Knapp, Spencer
Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate
title Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate
title_full Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate
title_fullStr Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate
title_full_unstemmed Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate
title_short Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate
title_sort biohybrid -se-s- coupling reactions of an amino acid derived seleninate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270073/
https://www.ncbi.nlm.nih.gov/pubmed/23381022
http://dx.doi.org/10.3390/molecules18021963
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AT sunzhexun biohybridsescouplingreactionsofanaminoacidderivedseleninate
AT knappspencer biohybridsescouplingreactionsofanaminoacidderivedseleninate

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