The Histone Deacetylase Inhibitors MS-275 and SAHA Suppress the p38 Mitogen-Activated Protein Kinase Signaling Pathway and Chemotaxis in Rheumatoid Arthritic Synovial Fibroblastic E11 Cells

MS-275 (entinostat) and SAHA (vorinostat), two histone deacetylase (HDAC) inhibitors currently in oncological trials, have displayed potent anti-rheumatic activities in rodent models of rheumatoid arthritis (RA). To further elucidate their anti-inflammatory mechanisms, the impact of MS-275 and SAHA...

Descripción completa

Detalles Bibliográficos
Autores principales: Choo, Qiu-Yi, Ho, Paul C, Tanaka, Yoshiya, Lin, Hai-Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270078/
https://www.ncbi.nlm.nih.gov/pubmed/24241152
http://dx.doi.org/10.3390/molecules181114085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270078/
https://www.ncbi.nlm.nih.gov/pubmed/24241152
http://dx.doi.org/10.3390/molecules181114085

Ejemplares similares