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A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation
This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with convention...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270084/ https://www.ncbi.nlm.nih.gov/pubmed/23736788 http://dx.doi.org/10.3390/molecules18066521 |
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author | Lin, Yung-Sheng Yang, Chih-Hui Wu, Chin-Tung Grumezescu, Alexandru Mihai Wang, Chih-Yu Hsieh, Wan-Chen Chen, Szu-Yu Huang, Keng-Shiang |
author_facet | Lin, Yung-Sheng Yang, Chih-Hui Wu, Chin-Tung Grumezescu, Alexandru Mihai Wang, Chih-Yu Hsieh, Wan-Chen Chen, Szu-Yu Huang, Keng-Shiang |
author_sort | Lin, Yung-Sheng |
collection | PubMed |
description | This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput. |
format | Online Article Text |
id | pubmed-6270084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62700842018-12-17 A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation Lin, Yung-Sheng Yang, Chih-Hui Wu, Chin-Tung Grumezescu, Alexandru Mihai Wang, Chih-Yu Hsieh, Wan-Chen Chen, Szu-Yu Huang, Keng-Shiang Molecules Article This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput. MDPI 2013-06-03 /pmc/articles/PMC6270084/ /pubmed/23736788 http://dx.doi.org/10.3390/molecules18066521 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Lin, Yung-Sheng Yang, Chih-Hui Wu, Chin-Tung Grumezescu, Alexandru Mihai Wang, Chih-Yu Hsieh, Wan-Chen Chen, Szu-Yu Huang, Keng-Shiang A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation |
title | A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation |
title_full | A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation |
title_fullStr | A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation |
title_full_unstemmed | A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation |
title_short | A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation |
title_sort | microfluidic chip using phenol formaldehyde resin for uniform-sized polycaprolactone and chitosan microparticle generation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270084/ https://www.ncbi.nlm.nih.gov/pubmed/23736788 http://dx.doi.org/10.3390/molecules18066521 |
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