Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mous...

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Autores principales: Thang, Tran Dinh, Kuo, Ping-Chung, Huang, Guan-Jhong, Hung, Nguyen Huy, Huang, Bow-Shin, Yang, Mei-Lin, Luong, Ngo Xuan, Wu, Tian-Shung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270106/
https://www.ncbi.nlm.nih.gov/pubmed/23591927
http://dx.doi.org/10.3390/molecules18044477
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author Thang, Tran Dinh
Kuo, Ping-Chung
Huang, Guan-Jhong
Hung, Nguyen Huy
Huang, Bow-Shin
Yang, Mei-Lin
Luong, Ngo Xuan
Wu, Tian-Shung
author_facet Thang, Tran Dinh
Kuo, Ping-Chung
Huang, Guan-Jhong
Hung, Nguyen Huy
Huang, Bow-Shin
Yang, Mei-Lin
Luong, Ngo Xuan
Wu, Tian-Shung
author_sort Thang, Tran Dinh
collection PubMed
description In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC(50) values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.
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spelling pubmed-62701062018-12-14 Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production Thang, Tran Dinh Kuo, Ping-Chung Huang, Guan-Jhong Hung, Nguyen Huy Huang, Bow-Shin Yang, Mei-Lin Luong, Ngo Xuan Wu, Tian-Shung Molecules Article In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC(50) values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM. MDPI 2013-04-16 /pmc/articles/PMC6270106/ /pubmed/23591927 http://dx.doi.org/10.3390/molecules18044477 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Thang, Tran Dinh
Kuo, Ping-Chung
Huang, Guan-Jhong
Hung, Nguyen Huy
Huang, Bow-Shin
Yang, Mei-Lin
Luong, Ngo Xuan
Wu, Tian-Shung
Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
title Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
title_full Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
title_fullStr Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
title_full_unstemmed Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
title_short Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production
title_sort chemical constituents from the leaves of annona reticulata and their inhibitory effects on no production
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270106/
https://www.ncbi.nlm.nih.gov/pubmed/23591927
http://dx.doi.org/10.3390/molecules18044477
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