Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds

Three new multiflorane-type triterpenes; 7α-methoxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3α,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with th...

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Detalles Bibliográficos
Autores principales: Kikuchi, Takashi, Takebayashi, Mika, Shinto, Mayumi, Yamada, Takeshi, Tanaka, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270121/
https://www.ncbi.nlm.nih.gov/pubmed/23673529
http://dx.doi.org/10.3390/molecules18055568
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author Kikuchi, Takashi
Takebayashi, Mika
Shinto, Mayumi
Yamada, Takeshi
Tanaka, Reiko
author_facet Kikuchi, Takashi
Takebayashi, Mika
Shinto, Mayumi
Yamada, Takeshi
Tanaka, Reiko
author_sort Kikuchi, Takashi
collection PubMed
description Three new multiflorane-type triterpenes; 7α-methoxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3α,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3α-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.
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spelling pubmed-62701212018-12-14 Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds Kikuchi, Takashi Takebayashi, Mika Shinto, Mayumi Yamada, Takeshi Tanaka, Reiko Molecules Article Three new multiflorane-type triterpenes; 7α-methoxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3α,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3α-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells. MDPI 2013-05-14 /pmc/articles/PMC6270121/ /pubmed/23673529 http://dx.doi.org/10.3390/molecules18055568 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kikuchi, Takashi
Takebayashi, Mika
Shinto, Mayumi
Yamada, Takeshi
Tanaka, Reiko
Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds
title Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds
title_full Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds
title_fullStr Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds
title_full_unstemmed Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds
title_short Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds
title_sort three new multiflorane-type triterpenes from pumpkin (cucurbita maxima) seeds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270121/
https://www.ncbi.nlm.nih.gov/pubmed/23673529
http://dx.doi.org/10.3390/molecules18055568
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