Cargando…

Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages

Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human epidermis, resulting in inflammation, photoaging, and photocarcinogenesis. Adequate protection of skin against the harmful effect of UV irradiation is essential. In recent years naturally occurring h...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Seoung Woo, Jung, Eunsun, Kim, Seungbeom, Lee, Kyung-Eun, Youm, Jong-Kyung, Park, Deokhoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270131/
https://www.ncbi.nlm.nih.gov/pubmed/23666007
http://dx.doi.org/10.3390/molecules18055405
_version_ 1783376627489570816
author Shin, Seoung Woo
Jung, Eunsun
Kim, Seungbeom
Lee, Kyung-Eun
Youm, Jong-Kyung
Park, Deokhoon
author_facet Shin, Seoung Woo
Jung, Eunsun
Kim, Seungbeom
Lee, Kyung-Eun
Youm, Jong-Kyung
Park, Deokhoon
author_sort Shin, Seoung Woo
collection PubMed
description Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human epidermis, resulting in inflammation, photoaging, and photocarcinogenesis. Adequate protection of skin against the harmful effect of UV irradiation is essential. In recent years naturally occurring herbal compounds such as phenolic acids, flavonoids, and high molecular weight polyphenols have gained considerable attention as beneficial protective agents. The simple phenolic veratric acid (VA, 3,4-dimethoxybenzoic acid) is one of the major benzoic acid derivatives from vegetables and fruits and it also occurs naturally in medicinal mushrooms which have been reported to have anti-inflammatory and anti-oxidant activities. However, it has rarely been applied in skin care. This study, therefore, aimed to explore the possible roles of veratric acid in protection against UVB-induced damage in HaCaT cells. Results showed that veratric acid can attenuate cyclobutane pyrimidine dimers (CPDs) formation, glutathione (GSH) depletion and apoptosis induced by UVB. Furthermore, veratric acid had inhibitory effects on the UVB-induced release of the inflammatory mediators such as IL-6 and prostaglandin-E2. We also confirmed the safety and clinical efficacy of veratric acid on human skin. Overall, results demonstrated significant benefits of veratric acid on the protection of keratinocyte against UVB-induced injuries and suggested its potential use in skin photoprotection.
format Online
Article
Text
id pubmed-6270131
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62701312018-12-14 Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages Shin, Seoung Woo Jung, Eunsun Kim, Seungbeom Lee, Kyung-Eun Youm, Jong-Kyung Park, Deokhoon Molecules Article Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human epidermis, resulting in inflammation, photoaging, and photocarcinogenesis. Adequate protection of skin against the harmful effect of UV irradiation is essential. In recent years naturally occurring herbal compounds such as phenolic acids, flavonoids, and high molecular weight polyphenols have gained considerable attention as beneficial protective agents. The simple phenolic veratric acid (VA, 3,4-dimethoxybenzoic acid) is one of the major benzoic acid derivatives from vegetables and fruits and it also occurs naturally in medicinal mushrooms which have been reported to have anti-inflammatory and anti-oxidant activities. However, it has rarely been applied in skin care. This study, therefore, aimed to explore the possible roles of veratric acid in protection against UVB-induced damage in HaCaT cells. Results showed that veratric acid can attenuate cyclobutane pyrimidine dimers (CPDs) formation, glutathione (GSH) depletion and apoptosis induced by UVB. Furthermore, veratric acid had inhibitory effects on the UVB-induced release of the inflammatory mediators such as IL-6 and prostaglandin-E2. We also confirmed the safety and clinical efficacy of veratric acid on human skin. Overall, results demonstrated significant benefits of veratric acid on the protection of keratinocyte against UVB-induced injuries and suggested its potential use in skin photoprotection. MDPI 2013-05-10 /pmc/articles/PMC6270131/ /pubmed/23666007 http://dx.doi.org/10.3390/molecules18055405 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shin, Seoung Woo
Jung, Eunsun
Kim, Seungbeom
Lee, Kyung-Eun
Youm, Jong-Kyung
Park, Deokhoon
Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages
title Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages
title_full Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages
title_fullStr Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages
title_full_unstemmed Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages
title_short Antagonist Effects of Veratric Acid against UVB-Induced Cell Damages
title_sort antagonist effects of veratric acid against uvb-induced cell damages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270131/
https://www.ncbi.nlm.nih.gov/pubmed/23666007
http://dx.doi.org/10.3390/molecules18055405
work_keys_str_mv AT shinseoungwoo antagonisteffectsofveratricacidagainstuvbinducedcelldamages
AT jungeunsun antagonisteffectsofveratricacidagainstuvbinducedcelldamages
AT kimseungbeom antagonisteffectsofveratricacidagainstuvbinducedcelldamages
AT leekyungeun antagonisteffectsofveratricacidagainstuvbinducedcelldamages
AT youmjongkyung antagonisteffectsofveratricacidagainstuvbinducedcelldamages
AT parkdeokhoon antagonisteffectsofveratricacidagainstuvbinducedcelldamages