In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16

The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathway...

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Autores principales: Du, Juan, Lu, Xiaonian, Long, Ziwen, Zhang, Zhen, Zhu, Xiaohua, Yang, Yongsheng, Xu, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270132/
https://www.ncbi.nlm.nih.gov/pubmed/23299553
http://dx.doi.org/10.3390/molecules18010757
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author Du, Juan
Lu, Xiaonian
Long, Ziwen
Zhang, Zhen
Zhu, Xiaohua
Yang, Yongsheng
Xu, Jinhua
author_facet Du, Juan
Lu, Xiaonian
Long, Ziwen
Zhang, Zhen
Zhu, Xiaohua
Yang, Yongsheng
Xu, Jinhua
author_sort Du, Juan
collection PubMed
description The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.
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spelling pubmed-62701322018-12-14 In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16 Du, Juan Lu, Xiaonian Long, Ziwen Zhang, Zhen Zhu, Xiaohua Yang, Yongsheng Xu, Jinhua Molecules Article The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future. MDPI 2013-01-08 /pmc/articles/PMC6270132/ /pubmed/23299553 http://dx.doi.org/10.3390/molecules18010757 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Du, Juan
Lu, Xiaonian
Long, Ziwen
Zhang, Zhen
Zhu, Xiaohua
Yang, Yongsheng
Xu, Jinhua
In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
title In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
title_full In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
title_fullStr In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
title_full_unstemmed In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
title_short In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
title_sort in vitro and in vivo anticancer activity of aconitine on melanoma cell line b16
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270132/
https://www.ncbi.nlm.nih.gov/pubmed/23299553
http://dx.doi.org/10.3390/molecules18010757
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