A New Triterpenoid from Teucrium viscidum

A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinores...

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Autores principales: Hao, Xincai, Zhang, Jinwen, Xia, Guangxin, Xue, Yongbo, Luo, Zengwei, Si, Yanyan, Yao, Guangmin, Zhang, Yonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270140/
https://www.ncbi.nlm.nih.gov/pubmed/23337296
http://dx.doi.org/10.3390/molecules18011262
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author Hao, Xincai
Zhang, Jinwen
Xia, Guangxin
Xue, Yongbo
Luo, Zengwei
Si, Yanyan
Yao, Guangmin
Zhang, Yonghui
author_facet Hao, Xincai
Zhang, Jinwen
Xia, Guangxin
Xue, Yongbo
Luo, Zengwei
Si, Yanyan
Yao, Guangmin
Zhang, Yonghui
author_sort Hao, Xincai
collection PubMed
description A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1–4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).
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spelling pubmed-62701402018-12-14 A New Triterpenoid from Teucrium viscidum Hao, Xincai Zhang, Jinwen Xia, Guangxin Xue, Yongbo Luo, Zengwei Si, Yanyan Yao, Guangmin Zhang, Yonghui Molecules Article A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1–4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). MDPI 2013-01-21 /pmc/articles/PMC6270140/ /pubmed/23337296 http://dx.doi.org/10.3390/molecules18011262 Text en © 2013 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hao, Xincai
Zhang, Jinwen
Xia, Guangxin
Xue, Yongbo
Luo, Zengwei
Si, Yanyan
Yao, Guangmin
Zhang, Yonghui
A New Triterpenoid from Teucrium viscidum
title A New Triterpenoid from Teucrium viscidum
title_full A New Triterpenoid from Teucrium viscidum
title_fullStr A New Triterpenoid from Teucrium viscidum
title_full_unstemmed A New Triterpenoid from Teucrium viscidum
title_short A New Triterpenoid from Teucrium viscidum
title_sort new triterpenoid from teucrium viscidum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270140/
https://www.ncbi.nlm.nih.gov/pubmed/23337296
http://dx.doi.org/10.3390/molecules18011262
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