Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb

Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and...

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Autores principales: Huang, Hui-Chi, Lin, Ming-Kuem, Hwang, Syh-Yuan, Hwang, Tsong-Long, Kuo, Yao-Haur, Chang, Chi-I, Ou, Chung-Yi, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270147/
https://www.ncbi.nlm.nih.gov/pubmed/23887717
http://dx.doi.org/10.3390/molecules18088752
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author Huang, Hui-Chi
Lin, Ming-Kuem
Hwang, Syh-Yuan
Hwang, Tsong-Long
Kuo, Yao-Haur
Chang, Chi-I
Ou, Chung-Yi
Kuo, Yueh-Hsiung
author_facet Huang, Hui-Chi
Lin, Ming-Kuem
Hwang, Syh-Yuan
Hwang, Tsong-Long
Kuo, Yao-Haur
Chang, Chi-I
Ou, Chung-Yi
Kuo, Yueh-Hsiung
author_sort Huang, Hui-Chi
collection PubMed
description Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.
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spelling pubmed-62701472018-12-18 Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb Huang, Hui-Chi Lin, Ming-Kuem Hwang, Syh-Yuan Hwang, Tsong-Long Kuo, Yao-Haur Chang, Chi-I Ou, Chung-Yi Kuo, Yueh-Hsiung Molecules Article Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB. MDPI 2013-07-24 /pmc/articles/PMC6270147/ /pubmed/23887717 http://dx.doi.org/10.3390/molecules18088752 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Hui-Chi
Lin, Ming-Kuem
Hwang, Syh-Yuan
Hwang, Tsong-Long
Kuo, Yao-Haur
Chang, Chi-I
Ou, Chung-Yi
Kuo, Yueh-Hsiung
Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb
title Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb
title_full Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb
title_fullStr Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb
title_full_unstemmed Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb
title_short Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb
title_sort two anti-inflammatory steroidal saponins from dracaena angustifolia roxb
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270147/
https://www.ncbi.nlm.nih.gov/pubmed/23887717
http://dx.doi.org/10.3390/molecules18088752
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