Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum

Three flavone-C-glycosides—cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)—were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum umbraculum, This is the first report of these compounds in this plant. All comp...

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Autores principales: Pham, Anh Thu, Nguyen, Celine, Malterud, Karl Egil, Diallo, Drissa, Wangensteen, Helle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270149/
https://www.ncbi.nlm.nih.gov/pubmed/24064447
http://dx.doi.org/10.3390/molecules180910312
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author Pham, Anh Thu
Nguyen, Celine
Malterud, Karl Egil
Diallo, Drissa
Wangensteen, Helle
author_facet Pham, Anh Thu
Nguyen, Celine
Malterud, Karl Egil
Diallo, Drissa
Wangensteen, Helle
author_sort Pham, Anh Thu
collection PubMed
description Three flavone-C-glycosides—cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)—were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum umbraculum, This is the first report of these compounds in this plant. All compounds were identified by spectroscopic analysis and comparison with published data. Isoorientin (3) and the EtOAc extract showed the greatest antioxidant activity in the DPPH assay as well as the strongest inhibition of xanthine oxidase (XO) and 15-lipoxygenase (15-LO). From these results, the extract of B. umbraculum might be a valuable source of flavone C-glycosides.
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spelling pubmed-62701492018-12-18 Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum Pham, Anh Thu Nguyen, Celine Malterud, Karl Egil Diallo, Drissa Wangensteen, Helle Molecules Article Three flavone-C-glycosides—cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)—were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum umbraculum, This is the first report of these compounds in this plant. All compounds were identified by spectroscopic analysis and comparison with published data. Isoorientin (3) and the EtOAc extract showed the greatest antioxidant activity in the DPPH assay as well as the strongest inhibition of xanthine oxidase (XO) and 15-lipoxygenase (15-LO). From these results, the extract of B. umbraculum might be a valuable source of flavone C-glycosides. MDPI 2013-08-26 /pmc/articles/PMC6270149/ /pubmed/24064447 http://dx.doi.org/10.3390/molecules180910312 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pham, Anh Thu
Nguyen, Celine
Malterud, Karl Egil
Diallo, Drissa
Wangensteen, Helle
Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum
title Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum
title_full Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum
title_fullStr Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum
title_full_unstemmed Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum
title_short Bioactive Flavone-C-Glycosides of the African Medicinal Plant Biophytum umbraculum
title_sort bioactive flavone-c-glycosides of the african medicinal plant biophytum umbraculum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270149/
https://www.ncbi.nlm.nih.gov/pubmed/24064447
http://dx.doi.org/10.3390/molecules180910312
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