Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels

Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H...

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Detalles Bibliográficos
Autores principales: Jiang, Hai Yan, Wang, Cheng Fang, Fan, Li, Yang, Kai, Feng, Jiang Bin, Geng, Zhu Feng, Xu, Jing, Deng, Zhi Wei, Du, Shu Shan, Yin, Hai Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270150/
https://www.ncbi.nlm.nih.gov/pubmed/24005969
http://dx.doi.org/10.3390/molecules180910768
Descripción
Sumario:Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4–6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC(50) values of 6.19 to 26.84 μg/mL.

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