Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels

Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H...

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Autores principales: Jiang, Hai Yan, Wang, Cheng Fang, Fan, Li, Yang, Kai, Feng, Jiang Bin, Geng, Zhu Feng, Xu, Jing, Deng, Zhi Wei, Du, Shu Shan, Yin, Hai Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270150/
https://www.ncbi.nlm.nih.gov/pubmed/24005969
http://dx.doi.org/10.3390/molecules180910768
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author Jiang, Hai Yan
Wang, Cheng Fang
Fan, Li
Yang, Kai
Feng, Jiang Bin
Geng, Zhu Feng
Xu, Jing
Deng, Zhi Wei
Du, Shu Shan
Yin, Hai Bo
author_facet Jiang, Hai Yan
Wang, Cheng Fang
Fan, Li
Yang, Kai
Feng, Jiang Bin
Geng, Zhu Feng
Xu, Jing
Deng, Zhi Wei
Du, Shu Shan
Yin, Hai Bo
author_sort Jiang, Hai Yan
collection PubMed
description Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4–6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC(50) values of 6.19 to 26.84 μg/mL.
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spelling pubmed-62701502018-12-18 Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels Jiang, Hai Yan Wang, Cheng Fang Fan, Li Yang, Kai Feng, Jiang Bin Geng, Zhu Feng Xu, Jing Deng, Zhi Wei Du, Shu Shan Yin, Hai Bo Molecules Article Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4–6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC(50) values of 6.19 to 26.84 μg/mL. MDPI 2013-09-03 /pmc/articles/PMC6270150/ /pubmed/24005969 http://dx.doi.org/10.3390/molecules180910768 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jiang, Hai Yan
Wang, Cheng Fang
Fan, Li
Yang, Kai
Feng, Jiang Bin
Geng, Zhu Feng
Xu, Jing
Deng, Zhi Wei
Du, Shu Shan
Yin, Hai Bo
Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels
title Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels
title_full Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels
title_fullStr Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels
title_full_unstemmed Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels
title_short Cytotoxic Constituents from the Stems of Clausena lansium (Lour.) Skeels
title_sort cytotoxic constituents from the stems of clausena lansium (lour.) skeels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270150/
https://www.ncbi.nlm.nih.gov/pubmed/24005969
http://dx.doi.org/10.3390/molecules180910768
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