The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The a...

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Detalles Bibliográficos
Autores principales: Brand, Guilherme D., Santos, Raimunda C., Arake, Luisa Mayumi, Silva, Valdelânia G., Veras, Leiz M. C., Costa, Vladimir, Costa, Carlos Henrique N., Kuckelhaus, Selma S., Alexandre, José Guilherme, Feio, Maria J., Leite, José Roberto S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270157/
https://www.ncbi.nlm.nih.gov/pubmed/23774944
http://dx.doi.org/10.3390/molecules18067058
Descripción
Sumario:Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.

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