The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The a...

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Autores principales: Brand, Guilherme D., Santos, Raimunda C., Arake, Luisa Mayumi, Silva, Valdelânia G., Veras, Leiz M. C., Costa, Vladimir, Costa, Carlos Henrique N., Kuckelhaus, Selma S., Alexandre, José Guilherme, Feio, Maria J., Leite, José Roberto S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270157/
https://www.ncbi.nlm.nih.gov/pubmed/23774944
http://dx.doi.org/10.3390/molecules18067058
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author Brand, Guilherme D.
Santos, Raimunda C.
Arake, Luisa Mayumi
Silva, Valdelânia G.
Veras, Leiz M. C.
Costa, Vladimir
Costa, Carlos Henrique N.
Kuckelhaus, Selma S.
Alexandre, José Guilherme
Feio, Maria J.
Leite, José Roberto S. A.
author_facet Brand, Guilherme D.
Santos, Raimunda C.
Arake, Luisa Mayumi
Silva, Valdelânia G.
Veras, Leiz M. C.
Costa, Vladimir
Costa, Carlos Henrique N.
Kuckelhaus, Selma S.
Alexandre, José Guilherme
Feio, Maria J.
Leite, José Roberto S. A.
author_sort Brand, Guilherme D.
collection PubMed
description Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.
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spelling pubmed-62701572018-12-17 The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides Brand, Guilherme D. Santos, Raimunda C. Arake, Luisa Mayumi Silva, Valdelânia G. Veras, Leiz M. C. Costa, Vladimir Costa, Carlos Henrique N. Kuckelhaus, Selma S. Alexandre, José Guilherme Feio, Maria J. Leite, José Roberto S. A. Molecules Article Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action. MDPI 2013-06-17 /pmc/articles/PMC6270157/ /pubmed/23774944 http://dx.doi.org/10.3390/molecules18067058 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Brand, Guilherme D.
Santos, Raimunda C.
Arake, Luisa Mayumi
Silva, Valdelânia G.
Veras, Leiz M. C.
Costa, Vladimir
Costa, Carlos Henrique N.
Kuckelhaus, Selma S.
Alexandre, José Guilherme
Feio, Maria J.
Leite, José Roberto S. A.
The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides
title The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides
title_full The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides
title_fullStr The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides
title_full_unstemmed The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides
title_short The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides
title_sort skin secretion of the amphibian phyllomedusa nordestina: a source of antimicrobial and antiprotozoal peptides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270157/
https://www.ncbi.nlm.nih.gov/pubmed/23774944
http://dx.doi.org/10.3390/molecules18067058
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