Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae

Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison wit...

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Detalles Bibliográficos
Autores principales: Suo, Maorong, Ohta, Tomihisa, Takano, Fumihide, Jin, Shouwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270160/
https://www.ncbi.nlm.nih.gov/pubmed/23797703
http://dx.doi.org/10.3390/molecules18077336
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author Suo, Maorong
Ohta, Tomihisa
Takano, Fumihide
Jin, Shouwen
author_facet Suo, Maorong
Ohta, Tomihisa
Takano, Fumihide
Jin, Shouwen
author_sort Suo, Maorong
collection PubMed
description Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, and compound 5 give the highest antioxidant activity among all compounds, with an IC(50) of 0.12 µM. All compounds exhibited moderate inhibitory effect on cytochrome CYP3A4 enzyme.
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spelling pubmed-62701602018-12-17 Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae Suo, Maorong Ohta, Tomihisa Takano, Fumihide Jin, Shouwen Molecules Article Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, and compound 5 give the highest antioxidant activity among all compounds, with an IC(50) of 0.12 µM. All compounds exhibited moderate inhibitory effect on cytochrome CYP3A4 enzyme. MDPI 2013-06-24 /pmc/articles/PMC6270160/ /pubmed/23797703 http://dx.doi.org/10.3390/molecules18077336 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Suo, Maorong
Ohta, Tomihisa
Takano, Fumihide
Jin, Shouwen
Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae
title Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae
title_full Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae
title_fullStr Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae
title_full_unstemmed Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae
title_short Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae
title_sort bioactive phenylpropanoid glycosides from tabebuia avellanedae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270160/
https://www.ncbi.nlm.nih.gov/pubmed/23797703
http://dx.doi.org/10.3390/molecules18077336
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AT takanofumihide bioactivephenylpropanoidglycosidesfromtabebuiaavellanedae
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