Cargando…

In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.

Eleven known caged polyprenylated xanthones 1–11 were isolated from the resin of Garcinia hanburyi Hook. f., and their structures were identified by their MS, NMR and UV spectra. These xanthones showed significant cytotoxicities against four human cancer cell lines (HeLa, A549, HCT-116, and HepG-2)...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jianhong, He, Shichao, Li, Shucai, Zhang, Ronghong, Peng, Aihua, Chen, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270171/
https://www.ncbi.nlm.nih.gov/pubmed/24335612
http://dx.doi.org/10.3390/molecules181215305
_version_ 1783376636299706368
author Yang, Jianhong
He, Shichao
Li, Shucai
Zhang, Ronghong
Peng, Aihua
Chen, Lijuan
author_facet Yang, Jianhong
He, Shichao
Li, Shucai
Zhang, Ronghong
Peng, Aihua
Chen, Lijuan
author_sort Yang, Jianhong
collection PubMed
description Eleven known caged polyprenylated xanthones 1–11 were isolated from the resin of Garcinia hanburyi Hook. f., and their structures were identified by their MS, NMR and UV spectra. These xanthones showed significant cytotoxicities against four human cancer cell lines (HeLa, A549, HCT-116, and HepG-2) and strong inhibition against the proliferation of the HUVEC cell line in vitro by the MTT method. Furthermore, in an in vivo zebrafish model, xanthones 3 (morellic acid), 7 (gambogenin) and 9 (isogambogenic acid) showed comparable antiangiogenic activities with less toxicities than xanthone 1 (gambogic acid), as evaluated by death and heart rates of treated zebrafish. Xanthone 7 exhibited antiangiogenic activity with no toxicity at concentrations ranging from 8 µM to 16 µM. Meanwhile, xanthones 1, 3, 7 and 9 strongly inhibited the migration of HUVEC at a low concentration of 0.5 µM in HUVEC cell migration assay in vitro. Taken together, these findings strongly suggest that xanthone 7 might be a novel angiogenesis inhibitor.
format Online
Article
Text
id pubmed-6270171
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62701712018-12-20 In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f. Yang, Jianhong He, Shichao Li, Shucai Zhang, Ronghong Peng, Aihua Chen, Lijuan Molecules Article Eleven known caged polyprenylated xanthones 1–11 were isolated from the resin of Garcinia hanburyi Hook. f., and their structures were identified by their MS, NMR and UV spectra. These xanthones showed significant cytotoxicities against four human cancer cell lines (HeLa, A549, HCT-116, and HepG-2) and strong inhibition against the proliferation of the HUVEC cell line in vitro by the MTT method. Furthermore, in an in vivo zebrafish model, xanthones 3 (morellic acid), 7 (gambogenin) and 9 (isogambogenic acid) showed comparable antiangiogenic activities with less toxicities than xanthone 1 (gambogic acid), as evaluated by death and heart rates of treated zebrafish. Xanthone 7 exhibited antiangiogenic activity with no toxicity at concentrations ranging from 8 µM to 16 µM. Meanwhile, xanthones 1, 3, 7 and 9 strongly inhibited the migration of HUVEC at a low concentration of 0.5 µM in HUVEC cell migration assay in vitro. Taken together, these findings strongly suggest that xanthone 7 might be a novel angiogenesis inhibitor. MDPI 2013-12-11 /pmc/articles/PMC6270171/ /pubmed/24335612 http://dx.doi.org/10.3390/molecules181215305 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yang, Jianhong
He, Shichao
Li, Shucai
Zhang, Ronghong
Peng, Aihua
Chen, Lijuan
In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.
title In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.
title_full In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.
title_fullStr In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.
title_full_unstemmed In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.
title_short In Vitro and In Vivo Antiangiogenic Activity of Caged Polyprenylated Xanthones Isolated from Garcinia hanburyi Hook. f.
title_sort in vitro and in vivo antiangiogenic activity of caged polyprenylated xanthones isolated from garcinia hanburyi hook. f.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270171/
https://www.ncbi.nlm.nih.gov/pubmed/24335612
http://dx.doi.org/10.3390/molecules181215305
work_keys_str_mv AT yangjianhong invitroandinvivoantiangiogenicactivityofcagedpolyprenylatedxanthonesisolatedfromgarciniahanburyihookf
AT heshichao invitroandinvivoantiangiogenicactivityofcagedpolyprenylatedxanthonesisolatedfromgarciniahanburyihookf
AT lishucai invitroandinvivoantiangiogenicactivityofcagedpolyprenylatedxanthonesisolatedfromgarciniahanburyihookf
AT zhangronghong invitroandinvivoantiangiogenicactivityofcagedpolyprenylatedxanthonesisolatedfromgarciniahanburyihookf
AT pengaihua invitroandinvivoantiangiogenicactivityofcagedpolyprenylatedxanthonesisolatedfromgarciniahanburyihookf
AT chenlijuan invitroandinvivoantiangiogenicactivityofcagedpolyprenylatedxanthonesisolatedfromgarciniahanburyihookf