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Lepidotrichilins A and B, New Protolimonoids with Cytotoxic Activity from Trichilia Lepidota (Meliaceae)

Two novel protolimonoids, named lepidotrichilins A (1) and B (2), four known protolimonoids, 21,23-epoxy-7α-21α-dihydroxyapotirucalla-14,24-dien-3-one (3), 21,23-epoxy-7α-21β-dihydroxyapotiru-calla-14,24-dien-3-one (4), dysorone D (5), deoxy-flindissone (6), and the two steroids β-sitosterol (7) and...

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Detalles Bibliográficos
Autores principales: Terra, Wagner da S., Vieira, Ivo J. C., Braz-Filho, Raimundo, de Freitas, William R., Kanashiro, Milton M., Torres, Maria Conceição M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270208/
https://www.ncbi.nlm.nih.gov/pubmed/24084021
http://dx.doi.org/10.3390/molecules181012180
Descripción
Sumario:Two novel protolimonoids, named lepidotrichilins A (1) and B (2), four known protolimonoids, 21,23-epoxy-7α-21α-dihydroxyapotirucalla-14,24-dien-3-one (3), 21,23-epoxy-7α-21β-dihydroxyapotiru-calla-14,24-dien-3-one (4), dysorone D (5), deoxy-flindissone (6), and the two steroids β-sitosterol (7) and stigmasterol (8) were identified in leaves of Trichilia lepidota subsp. schumanniana (Harms) T.D. Pennington. From wood the coumarin scopoletin (9) was isolated. The structures were established by NMR (1D (1)H and (13)C-NMR and 2D (1)H-(1)H COSY, HMQC and HMBC), mass spectroscopy and infrared (IR) spectral data. The hexane and methanol extracts of the leaves, the protolimonoids lepidotrichilins A (1) and B (2) (IC(50) 42.7 µg mL(−1)) and the protolimonoid deoxy-flindissone (6; IC(50) 9.3 µgmL(−1)) exhibited significant cytotoxic activity against the MOLT-4 and U937 leukemic cell lines.