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Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities

A new 8,4'-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2−7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (−)-(7...

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Autores principales: Xiong, Liang, Cao, Zhi-Xing, Peng, Cheng, Li, Xiao-Hong, Xie, Xiao-Fang, Zhang, Ting-Mo, Zhou, Qin-Mei, Yang, Lian, Guo, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270233/
https://www.ncbi.nlm.nih.gov/pubmed/23702921
http://dx.doi.org/10.3390/molecules18066153
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author Xiong, Liang
Cao, Zhi-Xing
Peng, Cheng
Li, Xiao-Hong
Xie, Xiao-Fang
Zhang, Ting-Mo
Zhou, Qin-Mei
Yang, Lian
Guo, Li
author_facet Xiong, Liang
Cao, Zhi-Xing
Peng, Cheng
Li, Xiao-Hong
Xie, Xiao-Fang
Zhang, Ting-Mo
Zhou, Qin-Mei
Yang, Lian
Guo, Li
author_sort Xiong, Liang
collection PubMed
description A new 8,4'-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2−7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (−)-(7S,8R,7'E)-4-hydroxy-3,3',5,5'-tetramethoxy-8,4'-oxyneolign-7'-ene-7,9,9'-triol 7,9'-bis-O-β-D-glucopyranoside (1). In the in vitro assays, compound 1 and (−)-syringaresinol-4,4'-bis-O-β-D-glucopyranoside (2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I (4) showed a selective cytotoxic activity with the IC(50) value of 4.17 μM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines.
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spelling pubmed-62702332018-12-17 Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities Xiong, Liang Cao, Zhi-Xing Peng, Cheng Li, Xiao-Hong Xie, Xiao-Fang Zhang, Ting-Mo Zhou, Qin-Mei Yang, Lian Guo, Li Molecules Article A new 8,4'-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2−7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (−)-(7S,8R,7'E)-4-hydroxy-3,3',5,5'-tetramethoxy-8,4'-oxyneolign-7'-ene-7,9,9'-triol 7,9'-bis-O-β-D-glucopyranoside (1). In the in vitro assays, compound 1 and (−)-syringaresinol-4,4'-bis-O-β-D-glucopyranoside (2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I (4) showed a selective cytotoxic activity with the IC(50) value of 4.17 μM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines. MDPI 2013-05-23 /pmc/articles/PMC6270233/ /pubmed/23702921 http://dx.doi.org/10.3390/molecules18066153 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xiong, Liang
Cao, Zhi-Xing
Peng, Cheng
Li, Xiao-Hong
Xie, Xiao-Fang
Zhang, Ting-Mo
Zhou, Qin-Mei
Yang, Lian
Guo, Li
Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
title Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
title_full Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
title_fullStr Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
title_full_unstemmed Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
title_short Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
title_sort phenolic glucosides from dendrobium aurantiacum var. denneanum and their bioactivities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270233/
https://www.ncbi.nlm.nih.gov/pubmed/23702921
http://dx.doi.org/10.3390/molecules18066153
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