Glycosyl-Nucleolipids as New Bioinspired Amphiphiles

Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybu...

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Detalles Bibliográficos
Autores principales: Latxague, Laurent, Patwa, Amit, Amigues, Eric, Barthélémy, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270249/
https://www.ncbi.nlm.nih.gov/pubmed/24084025
http://dx.doi.org/10.3390/molecules181012241
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author Latxague, Laurent
Patwa, Amit
Amigues, Eric
Barthélémy, Philippe
author_facet Latxague, Laurent
Patwa, Amit
Amigues, Eric
Barthélémy, Philippe
author_sort Latxague, Laurent
collection PubMed
description Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower γ(lim)) compared to the first generation of GNFs.
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spelling pubmed-62702492018-12-18 Glycosyl-Nucleolipids as New Bioinspired Amphiphiles Latxague, Laurent Patwa, Amit Amigues, Eric Barthélémy, Philippe Molecules Article Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower γ(lim)) compared to the first generation of GNFs. MDPI 2013-09-30 /pmc/articles/PMC6270249/ /pubmed/24084025 http://dx.doi.org/10.3390/molecules181012241 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Latxague, Laurent
Patwa, Amit
Amigues, Eric
Barthélémy, Philippe
Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
title Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
title_full Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
title_fullStr Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
title_full_unstemmed Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
title_short Glycosyl-Nucleolipids as New Bioinspired Amphiphiles
title_sort glycosyl-nucleolipids as new bioinspired amphiphiles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270249/
https://www.ncbi.nlm.nih.gov/pubmed/24084025
http://dx.doi.org/10.3390/molecules181012241
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