Efficient PPA-SiO(2)-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions

An efficient method has been developed for the synthesis of β-enaminones under solvent-free reaction conditions using PPA-SiO(2) as catalyst. The reaction yields were good to excellent (up to 90%). This methodology affords high selectivity and good tolerance of a variety of different functional grou...

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Detalles Bibliográficos
Autores principales: Nisar, Muhammad, Ali, Ihsan, Shah, Muhammad Raza, Qayum, Mughal, Zia-Ul-Haq, Muhammad, Rashid, Umer, Islam, Md. Saiful
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270262/
https://www.ncbi.nlm.nih.gov/pubmed/24335572
http://dx.doi.org/10.3390/molecules181215182
Descripción
Sumario:An efficient method has been developed for the synthesis of β-enaminones under solvent-free reaction conditions using PPA-SiO(2) as catalyst. The reaction yields were good to excellent (up to 90%). This methodology affords high selectivity and good tolerance of a variety of different functional groups present on both aromatic and aliphatic amines. In addition, the methodology is environmentally benign and cost-effective due to absence of solvent and easy work-up.

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