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The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate
Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide (4). In the last two decades, however, s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270269/ https://www.ncbi.nlm.nih.gov/pubmed/23389253 http://dx.doi.org/10.3390/molecules18022084 |
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author | Abdel-Aziz, Hatem A. Elsaman, Tilal Attia, Mohamed I. Alanazi, Amer M. |
author_facet | Abdel-Aziz, Hatem A. Elsaman, Tilal Attia, Mohamed I. Alanazi, Amer M. |
author_sort | Abdel-Aziz, Hatem A. |
collection | PubMed |
description | Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide (4). In the last two decades, however, some articles have claimed that this reaction afforded exclusively hydrazide 2 and they have reported the use of this hydrazide 2 as a precursor in the syntheses of several heterocyclic compounds and hydrazones 6. We reported herein a study of the formation of 2 and a facile route for the synthesis of the target compounds N'-arylidene-2-oxo-2H-chromene-3-carbohydrazides 6a–f. |
format | Online Article Text |
id | pubmed-6270269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62702692018-12-14 The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate Abdel-Aziz, Hatem A. Elsaman, Tilal Attia, Mohamed I. Alanazi, Amer M. Molecules Article Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide (4). In the last two decades, however, some articles have claimed that this reaction afforded exclusively hydrazide 2 and they have reported the use of this hydrazide 2 as a precursor in the syntheses of several heterocyclic compounds and hydrazones 6. We reported herein a study of the formation of 2 and a facile route for the synthesis of the target compounds N'-arylidene-2-oxo-2H-chromene-3-carbohydrazides 6a–f. MDPI 2013-02-06 /pmc/articles/PMC6270269/ /pubmed/23389253 http://dx.doi.org/10.3390/molecules18022084 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Abdel-Aziz, Hatem A. Elsaman, Tilal Attia, Mohamed I. Alanazi, Amer M. The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate |
title | The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate |
title_full | The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate |
title_fullStr | The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate |
title_full_unstemmed | The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate |
title_short | The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate |
title_sort | reaction of ethyl 2-oxo-2h-chromene-3-carboxylate with hydrazine hydrate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270269/ https://www.ncbi.nlm.nih.gov/pubmed/23389253 http://dx.doi.org/10.3390/molecules18022084 |
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