In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as...

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Autores principales: Attia, Mohamed I., Zakaria, Azza S., Almutairi, Maha S., Ghoneim, Soraya W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270279/
https://www.ncbi.nlm.nih.gov/pubmed/24084023
http://dx.doi.org/10.3390/molecules181012208
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author Attia, Mohamed I.
Zakaria, Azza S.
Almutairi, Maha S.
Ghoneim, Soraya W.
author_facet Attia, Mohamed I.
Zakaria, Azza S.
Almutairi, Maha S.
Ghoneim, Soraya W.
author_sort Attia, Mohamed I.
collection PubMed
description Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.
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spelling pubmed-62702792018-12-18 In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters Attia, Mohamed I. Zakaria, Azza S. Almutairi, Maha S. Ghoneim, Soraya W. Molecules Article Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent. MDPI 2013-09-30 /pmc/articles/PMC6270279/ /pubmed/24084023 http://dx.doi.org/10.3390/molecules181012208 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Attia, Mohamed I.
Zakaria, Azza S.
Almutairi, Maha S.
Ghoneim, Soraya W.
In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters
title In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters
title_full In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters
title_fullStr In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters
title_full_unstemmed In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters
title_short In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters
title_sort in vitro anti-candida activity of certain new 3-(1h-imidazol-1-yl)propan-1-one oxime esters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270279/
https://www.ncbi.nlm.nih.gov/pubmed/24084023
http://dx.doi.org/10.3390/molecules181012208
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