Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids

Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The syn...

Descripción completa

Detalles Bibliográficos
Autores principales: Hogendorf, Wouter F. J., Jagalski, Vivien, Pomorski, Thomas G., Bols, Mikael, Cárdenas, Marité, Pedersen, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270285/
https://www.ncbi.nlm.nih.gov/pubmed/24189295
http://dx.doi.org/10.3390/molecules181113546
_version_ 1783376663676977152
author Hogendorf, Wouter F. J.
Jagalski, Vivien
Pomorski, Thomas G.
Bols, Mikael
Cárdenas, Marité
Pedersen, Christian M.
author_facet Hogendorf, Wouter F. J.
Jagalski, Vivien
Pomorski, Thomas G.
Bols, Mikael
Cárdenas, Marité
Pedersen, Christian M.
author_sort Hogendorf, Wouter F. J.
collection PubMed
description Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed.
format Online
Article
Text
id pubmed-6270285
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62702852018-12-20 Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids Hogendorf, Wouter F. J. Jagalski, Vivien Pomorski, Thomas G. Bols, Mikael Cárdenas, Marité Pedersen, Christian M. Molecules Article Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed. MDPI 2013-11-01 /pmc/articles/PMC6270285/ /pubmed/24189295 http://dx.doi.org/10.3390/molecules181113546 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hogendorf, Wouter F. J.
Jagalski, Vivien
Pomorski, Thomas G.
Bols, Mikael
Cárdenas, Marité
Pedersen, Christian M.
Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids
title Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids
title_full Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids
title_fullStr Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids
title_full_unstemmed Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids
title_short Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids
title_sort synthesis and thermotropic phase behavior of four glycoglycerolipids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270285/
https://www.ncbi.nlm.nih.gov/pubmed/24189295
http://dx.doi.org/10.3390/molecules181113546
work_keys_str_mv AT hogendorfwouterfj synthesisandthermotropicphasebehavioroffourglycoglycerolipids
AT jagalskivivien synthesisandthermotropicphasebehavioroffourglycoglycerolipids
AT pomorskithomasg synthesisandthermotropicphasebehavioroffourglycoglycerolipids
AT bolsmikael synthesisandthermotropicphasebehavioroffourglycoglycerolipids
AT cardenasmarite synthesisandthermotropicphasebehavioroffourglycoglycerolipids
AT pedersenchristianm synthesisandthermotropicphasebehavioroffourglycoglycerolipids

Ejemplares similares